Purpose. The purpose of this study was to study the prevalence of peripheral retinal findings in adult Chinese patients with high myopia (refraction ≤-6.00 D) and to investigate the correlation between the retinal lesions and the severity of myopia or axial length.
Methods. A cross-sectional prevalence survey screening was conducted in high ethnic Chinese myopes with refractions equal to or less than -6.00 D. The examinations included cycloplegic refraction, A and B scan ultrasonography, and retinal examinations by indirect ophthalmoscopy with scleral indentation and Goldmann three-mirror contact lens examination.
Results. Two hundred thirteen eyes in 213 patients with a mean refraction of -10.10 ± 4.23 D (range = -6.00 to -27.00 D) were examined. The mean axial length was 26.69 ± 1.68 mm (range = 25.18–33.62 mm) and the mean age was 33.5 ± 10.6 years (range = 18–73 years). The most common peripheral retinal finding was pigmentary degeneration (51.2%), followed by lattice degeneration in 12.2% and retinal holes in 7.5% of eyes. A positive correlation was noted between axial length and the lesions of pigmentary degeneration and pavingstone degeneration. The prevalence of retinal holes was 6.4% and 30.0% in eyes with axial length of <30 mm and ≥30 mm, respectively (chi-squared test, p = 0.006).
Conclusion. A high prevalence of peripheral retinal degenerations was found in adult Chinese high myopes. The presence of retinal holes was positively correlated with very high myopia of an axial length of ≥30 mm.
Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, People’s Republic of China (DSCL, DSPF, WMC, AKHK,), the Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, People’s Republic of China (DSCL, DSPF, WMC, BSMT, ATSL, HP), the Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong, People’s Republic of China (AKHK), and the Outpatient Department, Hong Kong Baptist Hospital, Hong Kong, People’s Republic of China (ATSL)
Received April 5, 2004; accepted September 14, 2004.
Myopia is one of the most common ocular abnormalities.1 In the United States, 25% of the adult population were found to be myopic, whereas the prevalence rates were reported to be as high as 80% in Asian populations.1, 2 It can be classified as physiological or pathologic.3 Physiological myopia is a normal variation in the refractive error resulting from excessive convergent power caused by the cornea or the lens. Pathologic myopia is usually associated with an elongated globe and a refractive error of at least -6.00 D and/or an axial length of >25.5 mm.2, 3 The tissue alterations in high myopia affect the sclera, choroid, and retina, which can result in a number of ocular findings and potential complications.4–6
The prevalence of pathologic myopia or high myopia varies from 0.2–13.1% of the general population having the lowest prevalence in the black population and the highest in Asian populations.1, 2 High myopia with an increased axial length has been reported to be associated with a higher incidence of peripheral retinal degenerations such as lattice degeneration, retinal tears and holes, and an overall increased incidence of retinal detachment.5, 6 The prevalence varies widely, however, depending on the ethnic group examined, the method of examination, and the study criteria. Celorio4 found lattice degeneration in 33% of high myopes, whereas Kirker6 found only a 3% incidence in high myopes.
Similarly, earlier data about the correlation between axial length and peripheral retinal changes were inconsistent and sometimes conflicting. Pierro observed a positive correlation between longer axial length and the presence of lattice degeneration, paving stone degeneration, and white without pressure.5 This correlation, however, could not be shown between high myopia and peripheral retinal pigment, retinal tears and retinal detachment.5 Celorio noted the greatest prevalence of lattice degeneration in eyes with axial lengths of 26.0 to 26.9 mm (-6.00 to -8.70 D), but the prevalence of lattice degeneration exhibited an inverse relationship with even longer axial length.4 There were intrinsic limitations about these previous studies because the data were collected retrospectively, and recruited subjects were institution-based with a sample bias toward symptomatic individuals.
A community-based study screening asymptomatic patients with high myopia avoids many of the predispositions introduced by these previous studies. Like many Asian populations, Hong Kong Chinese people have a high prevalence of high myopia. The purpose of this community-based study was to determine the true prevalence and characteristics of peripheral retinal findings in high myopes of the Hong Kong Chinese population and to investigate the relationship among axial length, refractive error, and peripheral retinal degeneration. The results will help determine the necessity and type of ocular screening and disease prevention programs to be used in similar populations.
MATERIALS AND METHODS
This was a cross-sectional prevalence survey of high myopia (≤-6.00 D) conducted in October 1996. The protocol was approved by the Institutional Review Board at the Chinese University of Hong Kong and informed consent was obtained from each of the invited participants.
All subjects were recruited from the community after advertising through the media. The inclusion criteria were as follows: ethnic Chinese with myopia of ≤-6.00 D in at least one eye, an age of 18 years or older, and willingness to sign the study consent. Patients with a history of prematurity, retinal detachment, or those who had a full retinal examination in the past were excluded to minimize selection bias toward symptomatic patients. Eyes with media opacity such as corneal scar or cataract were also excluded from the study.
Each participant received a comprehensive ocular examination. This included best-corrected visual acuity (BCVA) with Snellen chart by certified optometrists, intraocular pressure (IOP) by noncontact tonometer (Rechert XPERT NCT Plus [Buffalo, NY]), slit-lamp anterior segment examination, noncycloplegic and cycloplegic autorefraction (Topcon KR 7100 [Japan]), and ultrasound biometry (A-scan; Storz Compuscan LT [St. Louis, MO]). A dilated retinal examination was performed in a dark room with indirect ophthalmoscope and scleral indentation together with biomicroscopy examination using a Goldmann three-mirror contact lens.
Ocular measurements, including refraction, spherical equivalent, IOP, findings of retinal status, and peripheral retinal lesions and axial length, were recorded.
A total of 213 patients with a refractive error of ≤-6.00 D by cycloplegic autorefraction were examined. One hundred seventy patients had bilateral high myopia, whereas 43 had unilateral high myopia. For those with bilateral high myopia, the correlation in spherical equivalent between the right and left eye was 0.87. The data of the right eye of these patients were used for further analysis. For unilateral cases, only the data of the highly myopic eyes were used. The mean age ± standard deviation (SD) was 33.5 ± 10.6 years (range = 18–73 years). The female to male percentage was 68.5% to 31.5%. The mean spherical equivalent ± SD was -10.10 ± 4.23 D (range = -6.00 to -27.00 D). The distribution of the spherical equivalent refraction in the screened population is shown in Figure 1. The mean astigmatism was -1.29 ± 1.13 D (range = 0.00 to -5.50 D). The measured axial length was 26.69 ± 1.68 mm (range = 25.18–33.62 mm) (Fig. 2). The refractive status was strongly correlated with increasing axial length (r = -0.753, p < 0.001). One hundred fifty-two of 213 eyes (71.4%) had peripheral retinal degeneration. Twenty-four eyes (11.3%) had a single discrete peripheral retinal degeneration, whereas most of the eyes (60.1%) had more than one lesion either of different pathology or at different sites (Table 1). Pigmentary degeneration was the most common peripheral retinal change and was present in 51.2% of eyes with high myopia. It was followed by white without pressure (31.0%) and lattice degeneration (12.2%). Retinal holes or breaks were found in 7.5% of patients and retinal detachment was seen in one eye (0.5%). Most of the lesions were found in the peripheral retina of temporal quadrants, and the prevalence of lesions in both superior and inferior quadrants was similar (Table 2).
The relative axial length was significantly greater in eyes with one or more lesions (27.01 ± 1.75 mm) compared with eyes that did not have any lesions (25.88 ± 1.19 mm) (t-test, p < 0.001). Pigmentary or pavingstone degeneration were more common in eyes with longer axial lengths (p < 0.001, p = 0.042, respectively) (Table 3). The same difference could not be demonstrated for peripheral lattice degeneration. The prevalence of retinal tears or holes was 6.4% and 30.0% in eyes with axial length of <30 mm and ≥30 mm, respectively (chi-squared test, p = 0.006).7
There have been numerous previous studies documenting peripheral retinal findings in myopes. In a general eye clinic, 600 consecutive patients with a mean refractive error of -1.77 D (range = +2.25 to -8.00 D) were studied prospectively and 5.2% were found to have lattice degeneration.8 In other studies, high myopes have been reported to have a greater prevalence of lattice degeneration.4–6, 9–11 Gozum et al. studied 212 eyes and reported that lattice degeneration was associated with high myopia and tended to increase with axial length, although the association did not reach statistical significance.10 Karlin et al. studied the retinal periphery of 1437 predominantly myopic eyes; their results revealed a statistically significant association of increasing axial length with four types of retinal degeneration, namely white without pressure, pigmentary degeneration, pavingstone degeneration, and lattice degeneration.11
Many of these reviews, however, showed a large variation in findings depending on the method of enrollment of patients (especially symptomatic and retinal-based practices) and the ethnic background of the subjects. High myopia is a significant ocular problem in Hong Kong partly because of its high prevalence in the Chinese population. Our study seeks to minimize the bias noted in some of the previous studies by using a community-based sample of subjects and by eliminating patients with a history of retinal problems. Although our study included a homogeneous population of Hong Kong Chinese adults, our study sample would have some bias as a result of self-selection of the patient population. However, the results of this study provide additional information on peripheral retinal findings in the ethnic Chinese population and allow for the planning and recommendation for future screening programs in Hong Kong.
The most common peripheral retinal lesion noted was pigmentary degeneration followed by white without pressure. Lattice degeneration was present in 12.2% of eyes, whereas retinal detachment was present in only 0.5% of this asymptomatic population. Retinal detachment is more common in eyes associated with the presence of peripheral retinal degeneration, especially lattice degeneration. There was an association between axial length and peripheral retinal findings (t-test, p < 0.001). Importantly, a very long axial length may be a risk factor for peripheral retinal tears or holes as demonstrated by a statistically significant correlation (p = 0.006). Only 6.4% of those with an axial length of <30.0 mm compared with 30.0% of those with an axial length of ≥30.0 mm have peripheral retinal tears or holes. Pierro also had similar findings in his study in which he found that eyes with white without pressure, paving stone degeneration, or lattice had a significantly greater axial length.5
The prevalence of lattice degeneration in highly myopic Chinese people is 12.2%, which is higher or at least similar to that reported in ethnic groups.4, 6 Although lattice degeneration is the most significant predisposing factor for retinal breaks or detachments, especially in eyes presenting with acute posterior vitreous detachment,12, 13 it was still not clear if these lesions should be routinely treated. Byer demonstrated a low incidence of retinal detachment in a prospective study of 276 consecutive untreated patients (423 eyes) with lattice degeneration. Clinical and subclinical retinal detachments occurred only in 0.7% and 6.7% of the eyes, respectively, and he suggested prophylactic treatment for lattice might not be justified and should be discontinued.14 However, the majority of the patients in Byer’s group were emmetropic or mildly myopic and relatively young in age. The low incidence of retinal detachments during the follow-up period may be associated with lesser occurrence of posterior vitreous separation during the study period in the study group.14–16
In a case–control study of idiopathic retinal detachment, myopia was demonstrated to be an important risk factor.15 In highly myopic patients reporting a high risk of detachment during their lifetime, the natural course or history of lattice degeneration may be different, and this is supported by studies in individuals with lattice degeneration and high myopia exceeding -5.0 D.16, 17 Burton recommended close follow-up of lattice degeneration in highly myopic patients and suggested prophylactic laser therapy.17 Tillery et al. also reported high myopia as an additional risk factor for phakic retinal detachment apart from the round atrophic holes in lattice degeneration.18
Knowing the accurate statistics of peripheral retinal lesions in highly myopic populations in Hong Kong will allow health policymakers to devise appropriate ocular screening or examination programs. Our study has demonstrated that lattice degeneration is a common peripheral retinal lesion in patients with refractive error of -6.00 D or less, and these were associated with longer axial length. In addition, other studies in highly myopic eyes have shown an increased incidence of retinal detachment in such eyes. In populations with high myopia, routine ocular screening examinations for peripheral lesions are recommended. Patients with findings of lattice degeneration should be informed about the symptoms of acute posterior vitreous detachment and retinal detachment, and be advised to report for ophthalmic evaluation should such symptoms occurs.
Supported in part by the Action For Vision (AFV) Eye Foundation, Hong Kong.
Dennis S. C. Lam
Department of Ophthalmology and Visual Sciences
The Chinese University of Hong Kong
3/F, Hong Kong Eye Hospital
147K Argyle Street
Kowloon, Hong Kong
1. Sperduto RD, Seigel D, Roberts J, Rowland M. Prevalence of myopia in the United States. Arch Ophthalmol 1983;101:405–7.
2. Wu HM, Seet B, Yap EP, Saw SM, Lim TH, Chia KS. Does education explain ethnic differences in myopia prevalence? A population-based study of young adult males in Singapore. Optom Vis Sci 2001;78:234–9.
3. Grossniklaus HE, Green WR. Pathologic findings in pathologic myopia. Retina 1992;12:127–33.
4. Celorio JM, Pruett RC. Prevalence of lattice degeneration and its relation to axial length in severe myopia. Am J Ophthalmol 1991;111:20–3.
5. Pierro L, Camesasca FI, Mischi M, Brancato R. Peripheral retinal changes and axial myopia. Retina 1992;12:12–7.
6. Kirker GE, McDonald DJ. Peripheral retinal degeneration in high myopia. Can J Ophthalmol 1971;6:58–61.
7. Fan DS, Lam DS, Li KK. Retinal complications after cataract extraction in patients with high myopia. Ophthalmology 1999;106:688–92.
8. Semes LP, Holland WC, Likens EG. Prevalence and laterality of lattice retinal degeneration within a primary eye care population. Optometry 2001;72:247–50.
9. Yura T. The relationship between the types of axial elongation and the prevalence of lattice degeneration of the retina. Acta Ophthalmol Scand 1998;76:90–5.
10. Gozum N, Cakir M, Gucukoglu A, Sezen F. Relationship between retinal lesions and axial length, age and sex in high myopia. Eur J Ophthalmol 1997;7:277–82.
11. Karlin DB, Curtin BJ. Peripheral chorioretinal lesions and axial length of the myopic eye. Am J Ophthalmol 1976;81:625–35.
12. Laatikainen L, Tolppanen EM. Characteristics of rhegmatogenous retinal detachment. Acta Ophthalmol (Copenh) 1985;63:146–54.
13. Benson WE, Morse PH. The prognosis of retinal detachment due to lattice degeneration. Ann Ophthalmol 1978;10:1197–200.
14. Byer NE. Long-term natural history of lattice degeneration of the retina. Ophthalmology 1989;96:1396–402.
15. The Eye Disease Case–Control Study Group. Risk factors for idiopathic rhegmatogenous retinal detachment. Am J Epidemiol 1993;137:749–57.
16. Lam DS, Tam BS, Chan W, Leung AT. Retinal breaks. Ophthalmology 1999;106:859–60.
17. Burton TC. The influence of refractive error and lattice degeneration on the incidence of retinal detachment. Trans Am Ophthalmol Soc 1989;87:143–57.
18. Tillery WV, Lucier AC. Round atrophic holes in lattice degeneration—an important cause of phakic retinal detachment. Trans Am Acad Ophthalmol Otolaryngol 1976;81:509–18.
Keywords:© 2005 American Academy of Optometry
prevalence; peripheral retinal degeneration; lattice; Chinese; high myopia; survey