Purpose: To investigate the correlation between the Ocular Surface Disease Index (OSDI) Questionnaire and noninvasive tear breakup times (NITBUTs) obtained by the Keratograph 4 (Oculus, Wetzlar, Germany) device.
Methods: A prospective sequential study of subjects (N = 99) unmatched for sex and without a significant difference in age by sex was performed. Testing included administration of OSDI, followed by Keratograph 4 measurements of the first NITBUT (NITBUTf) and average NITBUT (NITBUTav).
Results: The NITBUTf was significantly shorter than NITBUTav, as tested by Mann-Whitney statistic (U = 7331.5, <0.0001). The NITBUTf and NITBUTav demonstrated identical statistically significant Spearman correlations with OSDI (rs = −0.20, p = 0.05).
Conclusions: Ocular Surface Disease Index and NITBUT testing by Keratograph 4 device demonstrate a weak, but statistically significant, negative correlation.