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Effect of Oxybuprocaine Eye Drops on Corneal Volume and Thickness Measurements

Rosa, Nicola*; De Bernardo, Maddalena*; Borrelli, Maria*; Filosa, Maria Luisa*; Lanza, Michele*

doi: 10.1097/OPX.0b013e3182114303
Original Article

Purpose. To investigate the effect of oxybuprocaine eye drops on corneal volume (CV) and corneal thickness measurements.

Methods. Central corneal thickness (CCT), corneal thinnest point (CTP), and CV of 78 eyes of 78 healthy volunteers were measured with Pentacam, before and 5 min after the administration of oxybuprocaine eye drops. The fellow non-anesthetized eyes were used as control.

Results. Before topical anesthesia, the mean CCT was 546.76 ± 35.3 μm, after anesthesia, it was 547.76 ± 36.56 μm (p = 0.86). In the fellow eyes, the first mean CCT was 548.82 ± 35.2 μm and the second was 547.55 ± 35.9 μm (p = 0.82). The mean CTP before anesthesia was 543.99 ± 35.23 μm, after it was 544.89 ± 36.3 μm (p = 0.88). In the fellow eyes, the first mean CTP was 544.15 ± 35.35 μm and the second was 542.81 ± 36 μm (p = 0.81). Before topical anesthesia, the mean CV was 60.55 ± 3.84 mm3, after it was 60.66 ± 3.97 mm3 (p = 0.86). In the fellow eyes, the first mean CV was 60.93 ± 3.87 mm3 and the second was 60.73 ± 4 mm3 (p = 0.75).

Conclusions. Oxybuprocaine eye drops do not appear to induce a significant corneal swelling and do not affect the measurements when comparing CCT measured with optical or ultrasound devices.


Eye Department (NR, MB, ML), and Centro Grandi Apparecchiature (NR, MDB, MB, MLF, ML), Second University of Naples, Naples, Italy.

Received September 2, 2010; accepted December 3, 2010.

Nicola Rosa; Eye Department; Second University of Naples; Via Pansini 5; 80100 Naples, Italy; e-mail:

© 2011 American Academy of Optometry