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Sequential Versus Combined Penetrating Keratoplasty and Cataract Surgery

Cazabon, Sunildath*; Quah, Say Aun; Jones, Mark N. A.; Batterbury, Mark; Kaye, Stephen B.

doi: 10.1097/OPX.0b013e3181e1728e
Original Article

Purpose. To compare the refractive and visual outcomes of combined penetrating keratoplasty and cataract surgery (triple procedure) with those of sequential surgery (penetrating keratoplasty followed by secondary cataract extraction and posterior chamber intraocular lens implantation).

Methods. Forty-six consecutive patients undergoing triple procedure or sequential surgery performed by two surgeons were reviewed retrospectively. The triple procedure group consisted of 23 patients and the sequential surgery group also consisted of 23 patients. Refractive and visual outcomes were collected and analyzed with at least 1 year of follow-up for both groups. Both the difference from target and the variability of the refractive outcome were analyzed.

Results. Best spectacle corrected visual acuity of 6/12 or better was achieved in 16 eyes (69.8%) in the triple procedure group and in 19 eyes (82.6%) in the sequential surgery group. For both the triple and sequential groups, there was no difference between the mean postoperative refractive outcome (−2.73/+1.05 × 109 SD = 4.30/1.42/4.43) and (−1.33/+0.79 × 175 SD = 2.39/1.16/2.33) compared with the mean target refraction (−0.77, SD = 1.16 and −0.43, SD = 0.99), (p = 0.39 and 0.48), respectively. In addition, there was no significant difference in the variability of the refractive outcome between the two groups (p > 0.99).

Conclusions. Sequential surgery appears to offer no significant advantages over the triple procedure in terms of refractive predictability or variability. There was a slight trend toward more patients achieving 6/12 or better vision in the sequential group.




Ophthalmology Department, St Paul's Eye Unit, Royal Liverpool University Hospital, Prescott Street, Liverpool L7 8×P, United Kingdom (SC, SAQ, MB, SBK), and Transplant Department, UK Transplant, Fox Den Road, Stoke Gifford, Bristol, BS34 8RR, United Kingdom (MNAJ).

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Received November 16, 2009; accepted March 9, 2010.

© 2010 American Academy of Optometry