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Pathogenesis of Contact Lens-Associated Microbial Keratitis

Fleiszig, Suzanne M. J.*; Evans, David J.†

Optometry & Vision Science:
doi: 10.1097/OPX.0b013e3181d408ee

Sight-threatening microbial keratitis associated with contact lens wear remains a serious concern for patients, eye-care practitioners, and the contact lens industry. Several decades of research and some major advances in lens and solution technology have not resulted in a decline in disease incidence. Here, we offer a perspective on the complex pathogenesis of microbial keratitis, the factors that have prevented a better understanding of this disease, and new approaches being used to tackle this important clinical problem.

Author Information



Received December 25, 2009; accepted December 31, 2009.

School of Optometry and Graduate Programs in Vision Science, Microbiology, Infectious Disease and Immunity, and Health and Medical Sciences, University of California-Berkeley, Berkeley, California (SMJF, DJE), and College of Pharmacy, Touro University, California, Vallejo, California (DJE).

© 2010 American Academy of Optometry