Optometry & Vision Science

Skip Navigation LinksHome > October 2009 - Volume 86 - Issue 10 > Management of Symptomatic Meesmann Dystrophy
Optometry & Vision Science:
doi: 10.1097/OPX.0b013e3181baad27
Case Report

Management of Symptomatic Meesmann Dystrophy

Jalbert, Isabelle*; Stapleton, Fiona†

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Meesmann dystrophy is a non-progressive autosomal dominant corneal epithelial dystrophy characterized by intraepithelial cysts, which is likely to be caused by an intraepithelial metabolic abnormality. Cases may be asymptomatic or be associated with symptoms of irritation, lacrimation, and photophobia. Palliative treatment includes ocular lubricants, cycloplegia, and therapeutic contact lenses. In severe cases, management with epithelial debridement, phototherapeutic keratectomy, and lamellar keratoplasty has been advocated. Most recently, the genetic and molecular basis of Meesmann dystrophy have been explored, and mutations in the genes encoding corneal epithelial keratins have been reported. This report describes a case of Meesmann dystrophy with unusually severe symptoms and punctate epithelial keratopathy managed with a therapeutic contact lens.

© 2009 American Academy of Optometry


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