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Multitract Orthogonal Microelectrode Localization of the Subthalamic Nucleus: Description of a Novel Technique

Sweet, Jennifer A. MD*; Walter, Benjamin L. MD; Munyon, Charles MD*; Miller, Jonathan P. MD*

Operative Neurosurgery:
doi: 10.1227/NEU.0000000000000295
Technique Assessment
Abstract

BACKGROUND: Microelectrode recording helps surgeons accurately localize boundaries of the subthalamic nucleus (STN) and surrounding structures in deep brain stimulation.

OBJECTIVE: To describe a novel adaptation of the Ben gun device to optimize efficient mapping.

METHODS: Patients who underwent STN deep brain stimulation over a 3-year period were reviewed. For the final year, the Ben gun was rotated 45° and the target was offset 1.4 mm lateral and anterior in the plane orthogonal to the intended trajectory to allow for simultaneous parallel tracks at target, 2.8 mm anterior (localizing the front of STN), and 2.8 mm lateral (identifying the internal capsule). Before this step, the initial pass consisted of 1 to 2 tracks with the frame center targeted to STN. The primary outcome measure was the number of passes required for accurate localization of the nucleus and boundaries.

RESULTS: Eighty-three electrodes were implanted in 45 patients (mean age, 62; range, 37-78 years), of which 29 electrodes were placed by the use of the new technique. One electrode (4%) required more than 1 pass using the new technique compared with 36 (67%) using the older technique (P < .01). The distance from original target to final electrode position increased from 0.67 ± 0.13 mm to 1.06 ± 0.15 mm (P < .05) with a greater tendency to move the final electrode position posteriorly. There was no statistically significant difference in benefit from neurostimulation.

CONCLUSION: This technique facilitates reliable localization of the STN with fewer passes, possibly decreasing the risks associated with more passes and longer duration of surgery.

ABBREVIATIONS: DBS, deep brain stimulators

MER, microelectrode recording

PD, Parkinson disease

STN, subthalamic nucleus

Author Information

*Department of Neurological Surgery, University Hospitals Case Medical Center, Cleveland, Ohio;

Department of Neurology, University Hospitals Case Medical Center, Cleveland, Ohio

Correspondence: Jonathan P. Miller, MD, Department of Neurological Surgery, University Hospitals Case Medical Center, 11100 Euclid Ave, Cleveland, OH 44106. E-mail: jonathan.miller@uhhospitals.org

Received August 22, 2013

Accepted December 22, 2013

© 2014 by Lippincott Williams & Wilkins, Inc.

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