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Vaginal Progesterone as Maintenance Treatment After an Episode of Preterm Labour (PROMISE) Study: A Multicentre, Double-blind, Randomised, Placebo-Controlled Trial

Palacio, Montse; Cobo, Teresa; Antolín, Eugenia; Ramirez, M.; Cabrera, Francisco; Mozo de Rosales, Francisco; Bartha, José Luis; Juan, Miquel; Martí, Anna; Oros, Daniel; Rodríguez, A.; Scazzocchio, E.; Olivares, José María; Varea, Sara; Ríos, J.; Gratacós, Eduard; on behalf of the PROMISE Collaborative Group

Obstetrical & Gynecological Survey: March 2017 - Volume 72 - Issue 3 - p 151–153
doi: 10.1097/01.ogx.0000513224.85024.f9
Obstetrics: Obstetrical Complications

(Abstracted from BJOG 2016;123:1990–1999)

A large proportion of both short-term neonatal morbidity and mortality and long-term disability is associated with preterm birth. Women with previous preterm delivery, a short cervical length at midgestation, a twin pregnancy, and an episode of preterm labor arrested with tocolytic medication all have an increased risk of preterm delivery.

BCNatal, Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Fetal i+D Fetal Medicine Research Centre, IDIBAPS, University of Barcelona (M.P., T.C., E.G.); Centre for Biomedical Research on Rare Diseases (CIBER-ER) (M.P., T.C., E.G.), Barcelona; Hospital General Universitario Gregorio Marañón, Madrid (E.A.); Hospital Universitario Virgen Macarena, Sevilla (M.R.); Complejo Hospitalario Universitario Insular Materno Infantil, Las Palmas de Gran Canaria (F.C.); Hospital Universitario de Basurto, Bilbao (F.M.d.R.); Hospital Puerta del Mar, Cadiz (J.L.B.); Hospital de Son Llátzer, Mallorca (M.J.); Althaia Xarxa Assistencial Universitária de Manresa, Hospital de Sant Joan de Déu, Manresa (A.M.); Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria de Aragón, Red SAMID, RETICS, Zaragoza (D.O.); Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell (A.R.); Institut Universitari Parc Taulí—UAB. Universitat Autónoma de Barcelona (A.R.); Hospital Universitario Quirón-Dexeus (E.S.), Barcelona; Consorci Sanitari de Terrassa, Terrassa (J.M.O.); and Hospital Clínic of Barcelona, Clinical Trials Unit/Clinical Pharmacology Department (S.V.), and Biostatistics and Data Management Core Facility, IDIBAPS (J.R.), Hospital Clinic Barcelona; and Biostatistics Unit, School of Medicine, Universitat Autònoma de Barcelona (J.R.), Barcelona, Spain

Topics: Cervical length, preterm birth, preterm labor, progesterone.

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