(Abstracted from Hum Reprod 2017:32:201–207)
The underlying cause of primary ovarian insufficiency (POI) is unknown in most cases, which generally are referred to as idiopathic. Primary ovarian insufficiency is associated with biological reproductive aging and encompasses 3 stages: occult, biochemical, and overt.
Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University (X.X., X.C., X.Z., Z.W., P.W., Y.Q., Z.-J.C.); National Research Center for Assisted Reproductive Technology and Reproductive Genetics (X.X., X.C., X.Z., Z.W., P.W., Y.Q., Z.-J.C.); The Key laboratory of Reproductive Endocrinology (Shandong University) (X.X., X.C., X.Z., Z.W., P.W., Y.Q., Z.-J.C.), Jinan; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing (Y.L.); Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics (Y.D., Z.-J.C.); and Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai (Z.-J.C.), People’s Republic of China