Nearly all pregnant women experience nausea and vomiting of pregnancy (NVP) to some degree, yet its effects on quality of life (QOL) have not been studied extensively. The National Voice of Pregnancy survey was undertaken to increase understanding about the symptoms of NVP and their impact on QOL in women in the United States. In all, 621 currently or recently pregnant women completed an online survey about their NVP experiences. Their responses indicated that NVP can occur at any time of day or night and can have negative effects on eating, sleeping, and ability to handle domestic and occupational responsibilities. Relationships with spouse, family, friends, and coworkers can also be adversely affected. The effects of NVP are greater in women with moderate or severe symptoms, but women with mild NVP are also affected. These findings are consistent with previous studies conducted in various countries. Women sometimes fail to discuss NVP with their health care providers, and QOL issues rarely come up if it is discussed. Most women try dietary and other lifestyle modifications first to control their symptoms. Safe and effective medications are also available to help ease the symptoms of NVP and thereby improve QOL.