Skip Navigation LinksHome > July/August 2009 - Volume 44 - Issue 4 > Black Cohosh: Considerations of Safety and Benefit
Nutrition Today:
doi: 10.1097/NT.0b013e3181af63f9
Issues for the 2010 Dietary Guidelines

Black Cohosh: Considerations of Safety and Benefit

Betz, Joseph M. PhD; Anderson, Linda PhD; Avigan, Mark I. MD; Barnes, Joanne PhD; Farnsworth, Norman R. PhD; Gerdén, Barbro MD; Henderson, Leigh MS; Kennelly, Edward J. PhD; Koetter, Uwe PhD; Lessard, Stephanie MS; Dog, Tieraona Low MD, PhD; McLaughlin, Michelle BS; Naser, Belal MD; Osmers, Ruediger G. W. MD, PhD; Pellicore, Linda S. PhD; Senior, John R. PhD; van Breemen, Richard B. PhD; Wuttke, Wolfgang MD; Cardellina, John H. II PhD

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Abstract

Black cohosh, Actaea racemosa L (syn. Cimicifuga racemosa [L] Nutt), has enjoyed a rapid rise in popular use for the amelioration or alleviation of menopausal symptoms. At the same time, the last decade has witnessed a significant expansion of research on the chemistry, pharmacology, and clinical efficacy and safety of this botanical species. As a consequence of the growing body of data on black cohosh, together with the appearance of reports implicating this botanical in cases of liver damage, the Office of Dietary Supplements (National Institutes of Health) convened a workshop on the current state of knowledge for black cohosh (Gaithersburg, Maryland; June 2007); this review is based on that workshop. Based on the information presented and the ensuing discussions, several recommendations are proposed to facilitate better understanding and management of the safety of this botanical in the context of clinical trials

© 2009 Lippincott Williams & Wilkins, Inc.

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