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Grey Literature in Meta-Analyses

Conn, Vicki S.; Valentine, Jeffrey C.; Cooper, Harris M.; Rantz, Marilyn J.

Methods

Background In meta-analysis, researchers combine the results of individual studies to arrive at cumulative conclusions. Meta-analysts sometimes include “grey literature” in their evidential base, which includes unpublished studies and studies published outside widely available journals. Because grey literature is a source of data that might not employ peer review, critics have questioned the validity of its data and the results of meta-analyses that include it.

Objective To examine evidence regarding whether grey literature should be included in meta-analyses and strategies to manage grey literature in quantitative synthesis.

Methods This article reviews evidence on whether the results of studies published in peer-reviewed journals are representative of results from broader samplings of research on a topic as a rationale for inclusion of grey literature. Strategies to enhance access to grey literature are addressed.

Results The most consistent and robust difference between published and grey literature is that published research is more likely to contain results that are statistically significant. Effect size estimates of published research are about one-third larger than those of unpublished studies. Unfunded and small sample studies are less likely to be published. Yet, importantly, methodological rigor does not differ between published and grey literature.

Conclusions Meta-analyses that exclude grey literature likely (a) over-represent studies with statistically significant findings, (b) inflate effect size estimates, and (c) provide less precise effect size estimates than meta-analyses including grey literature. Meta-analyses should include grey literature to fully reflect the existing evidential base and should assess the impact of methodological variations through moderator analysis.

Vicki S. Conn, PhD, RN, is Professor and Associate Dean for Research, and Marilyn J. Rantz, PhD, RN, FAAN, is Professsor, School of Nursing;Jeffrey C. Valentine, PhD, is Research Assistant Professor, and Harris M. Cooper, PhD, is Professor, Department of Psychological Sciences; University of Missouri-Columbia.

Accepted for publication March 24, 2003.

Financial support provided by a grant from the NIH NINR (RO1NR07870) to Vicki Conn, principal investigator.

Corresponding author: Vicki S. Conn, PhD, RN, S317 School of Nursing-MU, Columbia, MO 65211 (e-mail: conn@missouri.edu)

© 2003 Lippincott Williams & Wilkins, Inc.