The NHLBI plans to release ATP IV in the spring of 2012.
Goals of lipid management
The first goal of lipid management is to keep the total cholesterol level under 200 mg/dL. Lifestyle modifications through dietary changes, weight loss, and exercise are started. If these changes don't decrease total cholesterol to under 200 mg/dL, then medications are started. Statins are the first line of pharmacologic treatment. However, if a patient also has a low HDL level and high triglycerides, fibric acid derivatives or niacin can be used. Combination therapy may be useful in targeting high LDL and triglyceride levels and low HDL.
Keeping the triglycerides under 150 mg/dL is the second goal of lipid management. Again, lifestyle modifications are the first step of treatment. When the triglyceride level is above 150 mg/dL, the patient requires conservative treatment; if triglyceride levels are above 200 mg/dL, the patient may be started on a fibric acid or niacin to target this lipoprotein alteration. The omega-3 fatty acids are also beneficial in lowering triglycerides levels by stopping the synthesis of VLDL in the liver.
Let's take a closer look at therapeutic lifestyle changes and pharmacologic management.
Therapeutic lifestyle changes
Therapeutic lifestyle changes can improve cholesterol levels. Changing the diet by decreasing fats is the first step (see The skinny on fats). It's important to keep the intake of saturated fats low and eliminate trans fats all together. In fact, eliminating trans fats from the diet can decrease the risk of cardiovascular disease up to 19%.
Eating lean cuts of meats and trimming visible fat and skin from meat before cooking can decrease saturated fat intake. When consuming dairy products, choosing low-fat cheeses, yogurts, and milk can help decrease fat intake. Avoiding margarines, salad dressings, and mayonnaise—all high in saturated and trans fats—is important. Canola oil or olive oil can be substituted for cooking and dressings. Educate your patients on reducing saturated fats by reading food labels and avoiding fast food eateries.
Fiber can also help lower cholesterol levels. Soluble fiber binds to the cholesterol we eat and helps the body eliminate it. There's also some evidence that soluble fiber can decrease the manufacture of cholesterol in the liver and make LDL particles less dense or easier to flow through the blood vessels.
The next step in therapeutic lifestyle changes is increasing physical activity. Help your patients accomplish this goal by providing instruction to start with aerobic exercise, such as walking every other day for at least 30 minutes as an initial step. Then, as endurance increases, the exercise routine can be changed to engaging in aerobic exercise for 40 minutes, 5 days each week. Because long-term compliance with an exercise program may be a problem, you can help your patients pick a plan that will be easy to follow, with favorite exercises and realistic workout times. You can also assist your patients to identify ways of incorporating more exercise in daily routines, such as using the stairs rather than an elevator.
The major classifications of medications to treat dyslipidemia are statins, bile acid sequestrants, cholesterol absorption inhibitors, nicotinic acid derivatives, and fibric acid derivatives (see Common medications used to treat dyslipidemia). Each has its benefits and adverse reactions.
Statins are most effective in lowering LDL cholesterol. They block the enzyme in the liver that controls the production of LDL. By reducing LDL levels, statins decrease the development of atherosclerotic plaque formations, decrease inflammation, and curtail the clotting response. Statins are only mildly effective in lowering triglycerides or increasing HDL levels. Some of the medications in this class are pravastatin, lovastatin, atorvastatin, simvastatin, fluvastatin, and rosuvastatin.
In general, statins are well tolerated, with minor adverse reactions such as gastrointestinal (GI) upset and headache. A more bothersome adverse reaction is muscle pain and weakness, which can be a sign of rhabdomyolysis (muscle breakdown). It's important to obtain a baseline phosphokinase (CPK) level and then repeat the test for any complaint of muscle pain and weakness. An elevated CPK would indicate that rhabdomyolysis is occurring. Also, if statins are combined with erythromycin, niacin, or gemfibrozil, the risk of myopathy may increase. Advise your patients to talk to their healthcare provider if they experience severe muscle pain or leg cramps.
Liver toxicity is another serious adverse reaction of statins. At the start of treatment, a baseline liver panel should be drawn, and then every 3 months to monitor liver function. If the patient has liver damage or drinks large amounts of alcohol, statins may not be the best drug treatment. In addition, statins should be used with caution in patients with compromised renal function. Proteinuria can occur, especially with rosuvastatin. If using high doses of these medications, renal function tests may be necessary.
There are minor differences among the statins. Atorvastatin is dose-related; increasing the dosage will reduce cholesterol more. Rosuvastatin and simvastatin can also decrease triglyceride levels and increase HDL levels, an advantage if your patient has changes on all three levels. Medications used to treat hypertension or arrhythmia can interfere with the metabolism of statins, resulting in increased plasma levels of the medications. It's important to educate your patients about possible drug interactions.
Most statins should be taken at bedtime because that's when a larger amount of cholesterol is produced. Exceptions are lovastatin, which works better when taken with food, and atorvastatin, which has a long half-life (peak levels of the medication will still occur during sleep).
Bile acid sequestrants bind the bile acids in the intestine and prevent reabsorption in the ileum. This disruption in the circulation of bile acids causes an increase in the conversion of cholesterol into bile acids, resulting in lower LDL levels. These medications are also effective at lowering triglyceride levels. Some of the medications in this class include cholestyramine, colestipol, and colesevelam.
Bile acids aren't absorbed, so adverse reactions are minimal. The most common adverse reactions are GI upset, including diarrhea, gas, nausea, and weight loss. Bile acid sequestrants should be taken with meals because they block cholesterol in the GI tract.
Bile acid sequestrants often come as powders or granules to be mixed with water, juice, or applesauce for better absorption. These medications have the potential to bind with other medications, such as thyroid hormones, fat-soluble vitamins, or antibiotics, decreasing their bioavailability. Advise your patients to take these medications either 1 hour before or 4 hours after taking a bile acid sequestrant.
Cholesterol absorption inhibitors, such as ezetimibe, cause mild lowering of LDL but aren't effective at raising HDL or lowering triglyceride levels. They decrease absorption of cholesterol in the small intestine, leading to a decrease of delivery to the liver. Adverse reactions include headache, diarrhea, and abdominal pain. Like the statins, any complaints of muscle pain or weakness should be taken seriously because rhabdomyolysis may occur.
Nicotinic acid derivatives inhibit the mobilization of free fatty acids from the peripheral tissues, reducing the hepatic synthesis of triglycerides. This decreases both the triglyceride and LDL levels and increases HDL levels. Patients taking niacin often experience flushing and itching for a short period after taking it. The flushing is caused by increased prostaglandins, and can be treated with 325 mg of aspirin half an hour before taking the niacin. Niacin can increase liver enzymes, uric acid, and glucose. A baseline fasting blood glucose level and liver panel should be obtained before starting the medications and every 6 months while on the medication. Also, niacin may not be the first choice for patients with diabetes or gout.
Fibric acid derivatives, such as fenofibrate and gemfibrozil, stop the production of VLDL and speed up the removal of triglycerides. Fibric acid derivatives are effective medications to help lower triglyceride levels. Gemfibrozil is also modestly effective in increasing HDL levels. The most common adverse reactions include GI upset, such as flatulence, dyspepsia, nausea, vomiting, and diarrhea. As with other cholesterol-lowering medications, liver toxicity can occur. Liver function tests should be obtained before the medication is started and every 3 months afterward.
Your role in successful outcomes
Nurses play a crucial role in lipid management programs by taking responsibility for getting patients involved in the treatment plan. Many studies demonstrate improvements in clinical outcomes and reduction of risk factors when a nurse is involved in care. Your role includes education, assessment and monitoring, consultation, and referral. Teach your patients about cholesterol and how abnormal levels can cause cardiovascular disease. Also teach about the lifestyle modifications that assist in improving the lipid profile.
Lipid-lowering agents are an integral part of management, and education about these drugs is a vital component of an effective lipid management program. At each visit, review your patients' medication profile and lab results and assess compliance with the treatment goals. You can act as a coach for your patients, encouraging compliance with meeting the goals of the treatment program. You can help your patients set realistic lifestyle modification goals and provide positive reinforcement when the steps to those goals are met.
In all these ways, nurses are important in securing successful outcomes for patients with dyslipidemia.
The skinny on fats
Fats provide energy and are essential to life. In our diet, there are unsaturated fats, saturated fats, and trans fats.
Unsaturated fats, found in plant-based products such as nuts, seeds, and vegetable oil, can decrease serum cholesterol levels and inflammation.
On the other hand, saturated fats can increase the risk of cardiovascular disease because they increase LDL levels. The body makes all the saturated fat it needs, so there's no need to eat any saturated fat in our diet. Major sources of saturated fats include meat, seafood, skinned chicken, whole milk dairy products, and coconut or palm oil.
Trans fats are made by hydrogenation. This is a process of heating liquid vegetable oils in the presence of hydrogen gas to make vegetable oil less likely to spoil and solidify it for ease of use. Trans fats are worse for cholesterol levels than other fats because they increase the LDL level and decease the HDL level. Trans fats also increase inflammation.
Therapeutic lifestyle changes
* Trim visible fat and skin from meat and poultry before cooking.
* Eat fish high in omega-3 fatty acids, such as salmon and trout.
* Select low-fat cheeses, milk, and yogurts.
* Cook with canola or olive oils.
* Decrease use of mayonnaise and salad dressings.
* Increase intake of fruits, vegetables, and legumes.
* Learn to read food labels and pick those with fresh ingredients.
* Switch from white rice or bread to whole grain products.
* In restaurants, watch the serving size; eat half and take home the rest.
* In fast food eateries, try lower-fat choices by avoiding sauces and fries.
Physical activity changes
* Pick a fitness plan with realistic goals, favorite exercises, and realistic workout times.
* Take the stairs instead of the elevator.
* Park the car far from the front door of stores.
* Walk during a lunch break.
* Increase aerobic exercise to 40 minutes, 5 days a week.
did you know?
The American Heart Association has updated its heart disease prevention guidelines for women. Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women—2011 Update focuses on understanding risks and applying measures likely to work in the "real world." Visit http://www.circ.ahajournals.org/cgi/reprint/CIR.0b013e31820faaf8v1 to download the new guidelines.
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