Institutional members access full text with Ovid®

Share this article on:

Non-Alzheimer types of neurodegenerative dementia: clinical and 18F-FDG-PET/CT pictures

Grassetto, Gaiaa; Marzola, Maria Cristinaa; Musto, Alessandrab; Viniamury, Sobhanc; Colletti, Patrick M.e; Perkins, Alan C.d; Rubello, Domenicoa

doi: 10.1097/MNM.0000000000000191
Review Article

Primary degenerative dementia syndromes are an increasingly relevant problem worldwide because of the progressive aging of the population. Their diagnosis is often a challenge for clinicians and, even in the best cases, only a possible or probable diagnosis can be reached. Molecular neuroimaging techniques can be very useful in dementia patients, especially for obtaining a diagnosis in the early stage of disease. The most diffuse and widely available nuclear medicine method for neurological studies is 18F-fluoro-deoxy-glucose (18F-FDG)-PET, which allows the quantification of glucose gray matter metabolism and helps visualize typical, adequately specific, patterns for many kinds of degenerative dementia, not only for the well-known and well-studied Alzheimer’s disease. This paper aims to describe the clinical and 18F-FDG-PET profiles of the principal non-Alzheimer type of degenerative dementias.

aNuclear Medicine Department, Santa Maria della Misericordia Hospital, Rovigo

bNuclear Medicine Department, Maggiore Hospital, Bologna, Italy

cNuclear Medicine Department, Royal Liverpool and Broadgreen University, Hospitals NHS Trust, Liverpool

dDepartment of Physics, University of Nottingham, Nottingham, UK

eDepartment of Radiology, University of Southern California, Los Angeles, California, USA

Correspondence to Gaia Grassetto, MD, Nuclear Medicine Department & PET/CT Centre, ‘Santa Maria della Misericordia’ Hospital, Via Tre Martiri 140, 45100 Rovigo, Italy Tel: +39 0425 39 4432; fax: +39 0425 39 4434; e-mail:

Received June 16, 2014

Received in revised form July 28, 2014

Accepted July 30, 2014

Copyright © 2014 Wolters Kluwer Health, Inc. All rights reserved.