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Image registration accuracy of an in-house developed patient transport system for PET/CT+MR and SPECT+CT imaging

Samarin, Andreia; Kuhn, Felix P.a; Brandsberg, Fredrikb; von Schulthess, Gustava; Burger, Irene A.a

Nuclear Medicine Communications: February 2015 - Volume 36 - Issue 2 - p 194–200
doi: 10.1097/MNM.0000000000000229
Original Articles

Objective: The aim of this study was to investigate the registration accuracy of a newly developed patient shuttle system that can integrate different scanners by patient transfer without repositioning for ‘hardware’-based image fusion. We aimed to assess the registration accuracy of image fusion in two different settings: a trimodality PET/CT+MR system and a SPECT+CT system.

Materials and methods: In this prospective study, 43 patients underwent either sequential PET/CT and MR (n=31) or sequential SPECT and diagnostic CT (D-CT) (n=12). A side-loading patient shuttle system was used for patient transport. For PET/CT+MR, hardware-only coregistration was performed and then validated with anatomical landmarks on CT and MR. SPECT+D-CT image fusion was performed with external cobalt-57 markers and manual fusion. Registration accuracy was analysed by anatomical landmarks on the attenuation correction CT and the D-CT.

Results: For the PET/CT+MR system, the mean offset between original CT and MR images in all 31 patients was 8.1±5.7 mm in the X-axis, 5±4 mm in the Y-axis and 4.9±5.6 mm in the Z-axis. The validation of the cobalt-57 marker-assisted SPECT+D-CT fusion yielded offsets of 0.7±1.7 mm in the X-axis, 2.1±1.7 mm in the Y-axis and 0.8±1.8 mm in the Z-axis.

Conclusion: Sequential PET/CT+MR and SPECT+D-CT imaging using a dedicated patient shuttle system is feasible, resulting in mean offsets between data sets of 10.7 mm using the gantry laser system and 2.4 mm with fiducial markers.

aDepartment of Nuclear Medicine, University Hospital of Zurich, Zurich

bInnovation Design Center, Thalwil, Switzerland

Correspondence to Andrei Samarin, MD, Department of Nuclear Medicine, University Hospital of Zurich, Ramistrasse 100, 8091 Zurich, Switzerland Tel: +41 44 255 3555; fax: +41 44 255 4414; e-mail:

Received March 20, 2014

Received in revised form July 28, 2014

Accepted September 13, 2014

© 2015 Wolters Kluwer Health | Lippincott Williams & Wilkins