Skip Navigation LinksHome > October 2014 - Volume 35 - Issue 10 > Dual-phase 18F-FDG PET/CT imaging in the characterization of...
Nuclear Medicine Communications:
doi: 10.1097/MNM.0000000000000157
Original Articles

Dual-phase 18F-FDG PET/CT imaging in the characterization of pancreatic lesions: does it offer prognostic information?

Santhosh, Sampatha; Mittal, Bhagwant R.a; Bhasin, Deepakb; Rana, Surinder S.b; Bhattacharya, Anisha; Srinivasan, Radhikac; Nada, Ritambhrad; Gupta, Rajeshe

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Objective: The primary aim of our prospective study was to evaluate the usefulness of dual-phase 18F-fluoro-deoxy-glucose PET/computed tomography (18F-FDG PET/CT) in the characterization of pancreatic masses. The secondary aim was to assess whether delayed imaging revealed any prognostic information.

Materials and methods: Fifty patients with periampullary or pancreatic masses on conventional imaging were included in this study. Early and delayed PET/CT was performed, followed by pathological examination in all patients. PET/CT parameters including uptake pattern, SUVearly, SUVdelayed, lesion to background ratio (L/B), and retention index (RI) were assessed for their ability to differentiate benign from malignant lesions. Patients with malignant lesions were followed up for a median duration of 26 months. The association of 11 variables with survival was analyzed by univariate and multivariate methods.

Results: Thirty-one patients had malignant lesions and 19 had benign lesions. The mean SUVearly, L/B, SUVdelayed, and RI between the malignant and benign lesions were statistically significant. The 18F-FDG uptake pattern of the lesions had higher sensitivity (93.5%) and specificity (100%) compared with RI (cutoff 25.7%) (84 and 37%, respectively) for diagnosing malignancy (P<0.05). In univariate analysis both RI (>18.7%) and tumor size (>2.6 cm) predicted significantly poor survival, whereas in multivariate analysis RI (P=0.04) was the only predictor of poor survival.

Conclusion: Dual-phase 18F-FDG PET/CT is not useful in characterizing pancreatic masses as it cannot differentiate benign from malignant lesions, and focal uptake on early PET imaging is the best indicator of malignancy. A possible benefit in performing a delayed scan is that a high RI (>18.7) can predict poor survival and hence may be useful in treatment planning.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins


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