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Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?

Martínez, Teresaa; Chivato, Tomásb; Roldán, Martab; Miñana, Elenab

Nuclear Medicine Communications:
doi: 10.1097/MNM.0000000000000103
Technical Note
Abstract

To avoid adverse effects during the administration of [123I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [123I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [123I] iodide on solid-phase extraction. No increase in percentages of free [123I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [123I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.

Author Information

aRadiopharmacy Unit, Santa Lucia’s Hospital, Cartagena

bRadiopharmacy Unit, Virgen de la Arrixaca Hospital, Murcia, Spain

Correspondence to Teresa Martínez, PhD, Radiopharmacy Unit, Santa Lucia’s Hospital, C/Mezquita, s/n, Paraje Los Arcos, 30202 Cartagena, Murcia, Spain Tel: +34 968 12 86 00 x950442; fax: +34 968 12 86 34; e-mails: tmmtnez@gmail.com, mteresa.martinez5@carm.es

Received February 4, 2014

Accepted February 13, 2014

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins