To avoid adverse effects during the administration of [123I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [123I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [123I] iodide on solid-phase extraction. No increase in percentages of free [123I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [123I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.
aRadiopharmacy Unit, Santa Lucia’s Hospital, Cartagena
bRadiopharmacy Unit, Virgen de la Arrixaca Hospital, Murcia, Spain
Correspondence to Teresa Martínez, PhD, Radiopharmacy Unit, Santa Lucia’s Hospital, C/Mezquita, s/n, Paraje Los Arcos, 30202 Cartagena, Murcia, Spain Tel: +34 968 12 86 00 x950442; fax: +34 968 12 86 34; e-mails: firstname.lastname@example.org, email@example.com
Received February 4, 2014
Accepted February 13, 2014