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Nuclear Medicine Communications:
doi: 10.1097/MNM.0000000000000103
Technical Note

Does intravenous saline infusion compromise the stability of [123I] meta-iodobenzylguanidine?

Martínez, Teresaa; Chivato, Tomásb; Roldán, Martab; Miñana, Elenab

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Abstract

To avoid adverse effects during the administration of [123I] meta-iodobenzylguanidine (MIBG), infusion of the drug that has been previously diluted is proposed. Stability of [123I] MIBG in sodium chloride solutions is studied, looking for incompatibilities in the formulation. Stability was tested on the basis of the percentage of free [123I] iodide on solid-phase extraction. No increase in percentages of free [123I] iodide was found in diluted and undiluted samples over time (P>0.05). Intravenous saline infusion of [123I] MIBG could be a useful tool for controlling the administration rate, minimizing the side effects and lowering the exposure of the staff to ionizing radiation.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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