Objectives: Accurate detection of recurrent cervical cancer remains a clinical difficulty. This study aims to assess the diagnostic value of PET or PET-computed tomography (PET-CT) using 18F-fluorodeoxyglucose (18F-FDG) in recurrent cervical cancer using a meta-analysis.
Study design: All published studies in English evaluating the diagnostic value of PET or PET-CT in detecting recurrent cervical cancer were collected. The methodological quality of the included studies was evaluated. Pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver-operating characteristic curves were obtained using statistical software. Twenty studies were included in the meta-analysis.
Results: The meta-analysis showed that the pooled sensitivity and specificity of PET and PET-CT to detect distant metastasis in recurrent cervical cancer were 0.87 [95% confidence interval (CI): 0.80–0.92] and 0.97 (95% CI: 0.96–0.98), respectively. The pooled sensitivity and specificity for local regional recurrence were 0.82 (95% CI: 0.72–0.90) and 0.98 (95% CI: 0.96–0.99), respectively.
Conclusion: 18F-FDG-PET and PET-CT are valuable methods for the assessment of recurrent cervical cancer.
aDepartment of Obstetric and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China
bDepartment of Obstetric and Gynecology, People's Hospital of Shanxi Province, 256 Xi'an Friendship West Road, Shanxi 710068, China
Correspondence to Ai Zheng, MD, Department of Obstetric and Gynecology, West China Second University Hospital, Sichuan University, Section 3, 20S. Renmin Road, Chengdu, Sichuan 610041, China Tel: +86 28 85503960; fax: +86 28 85559065; e-mail: firstname.lastname@example.org
Received September 10, 2013
Accepted October 1, 2013