Skip Navigation LinksHome > February 2014 - Volume 35 - Issue 2 > Diagnostic value of 18F-FDG-PET or PET-CT in recurrent cervi...
Nuclear Medicine Communications:
doi: 10.1097/MNM.0000000000000026
Original Articles

Diagnostic value of 18F-FDG-PET or PET-CT in recurrent cervical cancer: a systematic review and meta-analysis

Chu, Yanxiaa; Zheng, Aia; Wang, Feib; Lin, Weia; Yang, Xiaoyuna; Han, Linga; Chen, Yalia; Bai, Lipinga

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Abstract

Objectives: Accurate detection of recurrent cervical cancer remains a clinical difficulty. This study aims to assess the diagnostic value of PET or PET-computed tomography (PET-CT) using 18F-fluorodeoxyglucose (18F-FDG) in recurrent cervical cancer using a meta-analysis.

Study design: All published studies in English evaluating the diagnostic value of PET or PET-CT in detecting recurrent cervical cancer were collected. The methodological quality of the included studies was evaluated. Pooled sensitivity, specificity, diagnostic odds ratio, and summary receiver-operating characteristic curves were obtained using statistical software. Twenty studies were included in the meta-analysis.

Results: The meta-analysis showed that the pooled sensitivity and specificity of PET and PET-CT to detect distant metastasis in recurrent cervical cancer were 0.87 [95% confidence interval (CI): 0.80–0.92] and 0.97 (95% CI: 0.96–0.98), respectively. The pooled sensitivity and specificity for local regional recurrence were 0.82 (95% CI: 0.72–0.90) and 0.98 (95% CI: 0.96–0.99), respectively.

Conclusion: 18F-FDG-PET and PET-CT are valuable methods for the assessment of recurrent cervical cancer.

© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins

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