Purpose: The aim of the study was to evaluate UK-wide interinstitutional reproducibility of left-ventricular functional parameters, end-systolic volume, end-diastolic volume and ejection fraction, obtained from gated myocardial perfusion imaging (GMPI) studies using technetium-99m-labelled radiopharmaceuticals. The study was carried out by the UK Institute of Physics and Engineering in Medicine Nuclear Medicine Software Quality Group.
Materials and methods: Ten anonymized clinical GMPI studies, five with normal perfusion and five with perfusion defects, were made available in DICOM and proprietary formats for download and through manufacturers’ representatives. Two of the studies were duplicated in order to assess intraoperator repeatability, giving a total of 12 studies. Studies were made available in 8 and 16 frames/cycle.
Results: A total of 58 institutions across England, Scotland, Wales and Northern Ireland participated in this study using six different computer packages. Studies were processed at centres using their normal clinical computers and software. The overall mean±SD ejection fraction for all centres was 58.5±3%; the mean end-diastolic volume was 114±12 ml and the mean end-systolic volume was 54±6 ml. The results were affected by the number of frames per cycle and by the postprocessing computer package, but not by the reconstruction filter in the filtered back-projection.
Conclusion: Calculation of functional parameters from GMPI using technetium-99m-labelled radiopharmaceuticals is reliable and shows limited variability across the UK.
aRoyal United Hospital Bath NHS Trust, Bath
bDepartment of Medical Physics and Bioengineering, University Hospitals Bristol NHS Foundation Trust, Bristol
cLink Medical, Bramshill
dSunderland Royal Hospital, Sunderland
eCentral Manchester University Hospitals, Manchester
fGuy’s and St Thomas’ NHS Foundation Trust
gImperial College Healthcare NHS Trust, London
hBarnsley Hospital NHS Foundation Trust, Barnsley, UK
Data were presented at the Annual Congress of the European Association of Nuclear Medicine, 2012, and have been published as an abstract in Eur J Nucl Med Mol Imaging 2012; 39(Suppl 2): S171.
Correspondence to David O. Hall, PhD, Department of Medical Physics and Bioengineering, University Hospitals Bristol NHS Foundation Trust, Level 5 Old Building, Bristol Royal Infirmary, Upper Maudlin Street, Bristol, BS2 8HW, UK Tel: +44 117 342 4756; fax: +44 117 342 4570; e-mail: firstname.lastname@example.org
Received April 22, 2013
Accepted June 4, 2013