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The efficacy of montelukast as a protective agent against 131I-induced salivary gland damage in rats: scintigraphic and histopathological findings

Koca, Gökhana; Gültekin, Salih S.c; Han, Ünsald; Kuru, Serdarb; Demirel, Koraya; Korkmaz, Melihaa

Nuclear Medicine Communications: May 2013 - Volume 34 - Issue 5 - p 507–517
doi: 10.1097/MNM.0b013e32835ffecd
Original Articles

Aim: This study was designed to evaluate the efficiency of montelukast as a novel radioprotective agent against sodium [131I]iodide or potassium [131I]iodide (131I)-induced salivary gland damage in a rat model.

Materials and methods: The function and structure of salivary glands in 50 albino Wistar rats were evaluated with technetium-99m pertechnetate scintigraphies and histopathological examination. The animals were classified into five groups as follows: the control group (sham operated); group 1 (n=10; only 131I administration), group 2 (n=10; administration with 131I and montelukast); group 3 (n=10; 131I administration after total thyroidectomy); and group 4 (n=10; administration with 131I and montelukast after total thyroidectomy). All rats were killed at the end of the third month and three pairs of salivary glands were removed surgically.

Results: The scintigraphic evaluation revealed better results for groups administered montelukast than it did for other groups. Statistically significant differences (P<0.05 or P<0.001) were found between the control group and the other groups as well as between groups 1 and 3 (n=20) and groups 2 and 4 (n=20). However, there was no statistically significant difference (P>0.05) between groups 1 and 2 (n=20) and groups 3 and 4 (n=20). Histopathological examinations showed that pathological changes were significantly high in the groups treated with 131I without montelukast when compared with the other groups.

Conclusion: This is the first study on rats to assess the protective effect of montelukast on salivary glands after 131I therapy. According to our results, montelukast was found to be a potential protective agent against 131I-induced damage on salivary glands.

Department of aNuclear Medicine

bGeneral Surgery, Ministry of Health, Ankara Training and Research Hospital

Department of cNuclear Medicine

dPathology, Ministry of Health, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey

Correspondence to Salih S. Gültekin, MD, Department of Nuclear Medicine, Ministry of Health, Dişkapi Yildirim Beyazit Training and Research Hospital, Ankara 06110, Turkey Tel: +90 312 326 00 10 x1274; fax: +90 312 323 06 32; e-mail:

Received October 4, 2012

Accepted February 8, 2013

© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins