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Nuclear Medicine Communications:
doi: 10.1097/MNM.0b013e32832ed3cf
Original Articles

Effect of variation in relaxation parameter value on LOR-RAMLA reconstruction of 18F-FDG PET studies

Groheux, Davida; Martineau, Antoinea b; Vrigneaud, Jean-Marcc; Hindie, Elifa b; Baillet, Georgesa; Moretti, Jean-Luca b

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Purpose: We tested the impact of different values of the relaxation parameter lambda (λ) on contrast and noise in line-of-response row-action maximum likelihood algorithm (LOR-RAMLA) in 18F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) imaging.

Methods: Phantom studies were performed on a Gemini XL PET/CT scanner. The NEMA/IEC (National Electrical Manufacturers Association/International Electro technical Commission) torso phantom was used and acquisition data were reconstructed with λ values ranging from 0.025 to 0.1. Quality of the reconstructed images was evaluated by contrast recovery coefficients and background variability values according to the NEMA NU 2-2001 procedures.

Results: Contrast recovery coefficients and background variability increased significantly when λ increased. The best noise-versus-resolution trade-off was obtained with λ in the 0.04–0.06 range. For LOR-RAMLA reconstruction, the manufacturer allows a possible λ choice from 0.025 to 0.1. We would not advise too small (0.025) or too large (0.1) λ values which result in too smooth or too noisy images.

Conclusion: We determined optimal λ values in LOR-RAMLA on a Gemini XL PET/CT scanner. Caution is needed when using λ values out of that range.

© 2009 Lippincott Williams & Wilkins, Inc.


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