Skip Navigation LinksHome > October 2009 - Volume 30 - Issue 10 > Clinical significance of diffusely increased splenic uptake...
Nuclear Medicine Communications:
doi: 10.1097/MNM.0b013e32832fa254
Review Article

Clinical significance of diffusely increased splenic uptake on FDG-PET

Liu, Yiyan

Collapse Box

Abstract

Diffusely increased uptake is more commonly observed than focal uptake in the spleen on a whole-body [18F] fluorodeoxyglucose-positron emission tomography/computed tomography. The significance of diffusely increased splenic uptake varies in different clinical settings. On a pre-therapeutic scan for lymphoma, splenic uptake, greater than hepatic uptake, is a relative reliable indication of lymphomatous involvement of the spleen, unless the patient has a history of recent cytokine administration. In HIV infection, increased splenic uptake is usually noted in the early stage of the disease, which could reflect massive stimulation of B-cells in the spleen by nonreplicating antigenic material. Diffusely increased splenic uptake may also be present in sarcoidosis, malaria, and many inflammatory or hematopoietic diseases. Therapeutic-related reactive splenic uptake concurrent with bone marrow uptake is often secondary to administration of granulocyte colony-stimulating factor for myelosuppression or high-dose interferon-α-2b adjuvant therapy for melanoma.

© 2009 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.