Skip Navigation LinksHome > March 2014 - Volume 39 - Issue 3 > Conjunctival MALT Lymphoma: Utility of FDG PET/CT for Diagno...
Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000356
Interesting Images

Conjunctival MALT Lymphoma: Utility of FDG PET/CT for Diagnosis, Staging, and Evaluation of Treatment Response

Sallak, Asmaa MD*; Besson, Florent L. MD*; Pomoni, Anastasia MD*; Christinat, Alexandre MD; Adler, Marcel MD; Aegerter, Jean-Philippe MD; Nguyen, Christophe MD§; de Leval, Laurence MD, PhD; Frossard, Valérie MD; Prior, John O. PhD, MD*

Open Access
Article Outline
Collapse Box

Author Information

From the Departments of *Nuclear Medicine, †Oncology, and ‡Hematology, Lausanne University Hospital; §Jules Gonin Eye Hospital; ¶Department of Pathology, Lausanne University Hospital, Lausanne; and ∥Department of Oncology, Sion Hospital, Sion, Switzerland.

Received for publication July 8, 2013; revision accepted December 11, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: John O. Prior, PhD, MD, Department of Nuclear Medicine, Lausanne University Hospital, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland. E-mail:

Collapse Box


A 67-year-old woman was referred for staging of a mucosa-associated lymphoid tumor lymphoma involving the left conjunctiva. CT scan had shown paravertebral and pelvic masses, and a breast nodule. FDG PET/CT demonstrated moderately increased uptake in the left ocular conjunctiva and confirmed the paravertebral and pelvic masses and the breast nodule. Moreover, abnormal FDG uptake was shown in 2 breast nodules, the flank, the gluteus maximus, and the gastric cardia. The patient received 6 cycles of rituximab-bendamustine chemotherapy with a complete clinical and metabolic response at the 6-month follow-up PET/CT and remained relapse-free without visual acuity problem after a 36-month follow-up.
Image Tools
Image Tools
Back to Top | Article Outline


1. Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin’s lymphomas: distributions of the major subtypes differ by geographic locations. Non-Hodgkin’s Lymphoma Classification Project. Ann Oncol. 1998; 9: 717–720.

2. Thomas AG, Vaidhyanath R, Kirke R, et al. Extranodal lymphoma from head to toe: part 1, the head and spine. AJR Am J Roentgenol. 2011; 197: 350–356.

3. Matsuo T, Ichimura K, Tanaka T, et al. Conjunctival lymphoma can be detected by FDG PET. Clin Nucl Med. 2012; 37: 516–519.

4. Hayashi D, Devenney-Cakir B, Lee JC, et al. Mucosa-associated lymphoid tissue lymphoma: multimodality imaging and histopathologic correlation. AJR Am J Roentgenol. 2010; 195: W105–W117.

5. Gayed I, Eskandari MF, McLaughlin P, et al. Value of positron emission tomography in staging ocular adnexal lymphomas and evaluating their response to therapy. Ophthalmic Surg Lasers Imaging. 2007; 38: 319–325.

6. Abdelmalik AG, Fajnwaks P, Osman MM, et al. Squamous cell carcinoma of the bulbar conjunctiva seen on F-18 FDG PET/CT. Clin Nucl Med. 2010; 35: 962–964.

7. Lin LF, Chang CY, Cherng SC. Advanced squamous cell carcinoma of the bulbar conjunctiva seen on PET/CT. Clin Nucl Med. 2008; 33: 929–930.

8. Zanni M, Moulin-Romsee G, Servois V, et al. Value of 18FDG PET scan in staging of ocular adnexal lymphomas: a large single-center experience. Hematology. 2012; 17: 76–84.

9. Stefanovic A, Lossos IS. Extranodal marginal zone lymphoma of the ocular adnexa. Blood. 2009; 114: 501–510.

10. Dabbagh Kakhki VR. 18F-FDG-PET, gallium-67 and somatostatin receptor scintigraphy, in ocular MALT lymphoma. Hell J Nucl Med. 2008; 11: 49

author reply 50


18F; FDG; PET; ocular lymphoma; MALT; ocular adnexal MALT lymphoma; conjunctival MALT lymphoma

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License, where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.

Copyright © 2014 by Lippincott Williams & Wilkins


Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.