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Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e318224b814
Original Article

ACR–ASTRO Practice Guideline for the Performance of Therapy With Unsealed Radiopharmaceutical Sources

Henkin, Robert E. MD*; Del Rowe, John D. MD†; Grigsby, Perry W. MD‡; Hartford, Alan C. MD, PhD§; Jadvar, Hossein MD, PhD, MPH, MBA¶; Macklis, Roger M. MD∥; Parker, J. Anthony MD, PhD**; Wong, Jeffrey Y. C. MD††; Rosenthal, Seth A. MD‡‡

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From the *Department of Nuclear Medicine, Loyola University Medical Center, Maywood, IL; †Department of Radiation Oncology, North Shore University Hospital, Manhasset, NY; ‡Department of Radiation Oncology, Washington University Medical Center, St. Louis, MO; §Section of Radiation Oncology, Dartmouth-Hitchcock Medical Center, Lebanon, NH; ¶Department of Radiology, University of Southern California, Los Angeles, CA; ∥Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH; **Department of Nuclear Medicine, Beth Israel Deaconess Medical Center, Boston, MA; ††Department of Radiation Oncology and Radiation Research, City of Hope Medical Center, Duarte, CA; and ‡‡Radiation Oncology Centers, Radiological Association of Sacramento, Sacramento, CA.

Received for publication May 12, 2011; revision accepted May 16, 2011.

Robert E. Henkin, paid design consultant to Philips Electronics.

Reprints: American College of Radiology, Department of Quality and Safety—Guidelines and Standards, 1891 Preston White Dr., Reston, VA 20191.

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This guideline is intended to guide appropriately trained and licensed physicians performing therapy with unsealed radiopharmaceutical sources. Adherence to this guideline should help to maximize the efficacious use of these procedures, maintain safe conditions, and ensure compliance with applicable regulations. The topics dealt with in this guideline include indications for the use of iodine-131, both for the treatment of hyperthyroidism and thyroid carcinoma. In addition, indications for other less common procedures include those for the use of phosphorous-32 in its liquid and colloidal forms, strontium-89, samarium-153, and the use of Y-90 antibodies.

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These guidelines are an educational tool designed to assist practitioners in providing appropriate radiologic and radiation oncology care for patients. They are not inflexible rules or requirements of practice and are not intended, nor should they be used, to establish a legal standard of care. For these reasons and those set forth below, the American College of Radiology (ACR) cautions against the use of these guidelines in litigation in which the clinical decisions of a practitioner are called into question.

The ultimate judgment regarding the propriety of any specific procedure or course of action must be made by the physician or medical physicist in light of all the circumstances presented. Thus, an approach that differs from the guidelines, standing alone, does not necessarily imply that the approach was below the standard of care. To the contrary, a conscientious practitioner may responsibly adopt a course of action different from that set forth in the guidelines when, in the reasonable judgment of the practitioner, such course of action is indicated by the condition of the patient, limitations of available resources, or advances in knowledge or technology subsequent to publication of the guidelines. However, a practitioner who employs an approach substantially different from these guidelines is advised to document in the patient record information sufficient to explain the approach taken.

The practice of medicine involves not only the science, but also the art of dealing with the prevention, diagnosis, alleviation, and treatment of disease. The variety and complexity of human conditions make it impossible to always reach the most appropriate diagnosis or to predict with certainty a particular response to treatment.

Therefore, it should be recognized that adherence to these guidelines will not assure an accurate diagnosis or a successful outcome. All that should be expected is that the practitioner will follow a reasonable course of action based on current knowledge, available resources, and the needs of the patient to deliver effective and safe medical care. The sole purpose of these guidelines is to assist practitioners in achieving this objective.

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This guideline was revised by the ACR, and the American Society for Radiation Oncology (ASTRO).

This guideline is intended to guide appropriately trained and licensed physicians performing therapy with unsealed radiopharmaceutical sources. Such therapy requires close cooperation and communication between the physicians who are responsible for the clinical management of the patient and those who administer radiopharmaceutical therapy and manage the attendant side effects. Adherence to this guideline should help to maximize the efficacious use of these procedures, maintain safe conditions, and ensure compliance with applicable regulations.

Application of this guideline should be in accordance with the ACR Technical Standard for Diagnostic Procedures Using Radiopharmaceuticals,1 as that guideline relates to the handling of radiopharmaceuticals; radiation safety; and radiation protection of patients, personnel, and the public. There must also be compliance with applicable laws and regulations.

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Therapy with unsealed sources involves administration of radiopharmaceuticals for the treatment of medical conditions.

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The goal of therapy with unsealed radiopharmaceutical sources is to provide either cure or effective palliation of disease while minimizing untoward side effects and complications.

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Examples of therapy with unsealed radiopharmaceutical sources include, but are not limited to:

1. Iodine-131 (sodium iodide) for treatment of hyperthyroidism.

2. Iodine-131 (sodium iodide) for ablation of postoperative thyroid remnant and for therapy of iodine-avid thyroid cancer.

3. Phosphorus-32 (sodium phosphate) for treatment of myeloproliferative disorders such as polycythemia vera and thrombocytosis.

4. Phosphorus-32 (colloidal chromic phosphate) for intracavitary therapy for malignant ascites, malignant pleural effusions, malignant pericardial effusions, and malignant brain cysts.

5. Strontium-89 (strontium chloride) and samarium-153 lexidronam ethylene diamine tetramethylene phosphonic acid for adjuvant and palliative treatment of painful skeletal metastases when these metastases are radiotracer-avid on a diagnostic bone scan.

6. Yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab, murine monoclonal antibodies that target the CD20 antigen, for treatment of patients with CD20 positive follicular B-cell non-Hodgkin lymphoma, with or without transformation, including but not limited to the disease that is refractory to rituximab and has relapsed following chemotherapy. On September 3, 2009, the FDA granted expanded approval for the use of yttrium-90 ibritumomab tiuxetan in patients with previously untreated follicular non-Hodgkin lymphoma who have demonstrated partial or complete response to first-line chemotherapy (consolidation after chemotherapy).2,3

More information on radioembolization is given in the ACR–ASTRO–SIR Practice Guideline for Radioembolization with Microsphere Brachytherapy Device for treatment of liver malignancies.4

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The qualifications and responsibilities of physicians and other personnel performing these therapeutic procedures should be in accordance with the ACR Technical Standard for Diagnostic Procedures Using Radiopharmaceuticals1 and/or the ACR Practice Guideline for Radiation Oncology.5 In addition, training and experience must be in compliance with the applicable laws and regulations.

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The written or electronic request for a radiopharmaceutical procedure should provide sufficient information to demonstrate the medical necessity of the examination and allow for its proper performance. Documentation that satisfies medical necessity includes (1) signs and symptoms and/or (2) relevant history (including known diagnoses). Additional information regarding the specific reason for the procedure or diagnosis would be helpful and may at times be needed to allow for the proper performance of the procedure.

The request for the procedure must be originated by a physician or other appropriately licensed healthcare provider. The accompanying clinical information should be provided by a physician or other appropriately licensed healthcare provider familiar with the patient's clinical problem or question and consistent with the state's scope of practice requirements (ACR Resolution 35, adopted in 2006).

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A. General Procedures

1. Clinical evaluation—The initial evaluation includes review of the patient's history, physical examination, and pertinent diagnostic studies and reports. A complete history of all previous radiotherapy and radiopharmaceutical therapy and communication with the referring physician and other physicians involved in the patient's care are also recommended. For the radiopharmaceutical treatments that are potentially marrow-toxic, a complete blood count with differential and platelet count should be a part of the initial evaluation and of each pretreatment examination.

2. Quality management—To use radiopharmaceuticals as unsealed sources for therapy, a “quality management” program must be in place as required by the Nuclear Regulatory Commission (NRC) or agreement state (An agreement state is any state with which the US NRC or the US Atomic energy Commission has entered into an effective agreement under Subsection 274.b of the Atomic Energy Act of 1954, as amended [73 Stat. 689]) regulations. Key elements of this program are as follows: written directives; duplicative procedures for identifying patients; careful record keeping to ensure prescribed administered activity; minimization of the possibility of infiltration for agents that are administered intravenously; procedures for minimizing radiation exposure or radiopharmaceutical contamination of personnel, family members of patients, and the public (eg, alerts regarding possible current or future pregnancy); procedures for containment of radioactivity; and an audit mechanism to ensure compliance with the program.

3. Informed consent—Informed consent must be obtained and documented. See the ACR Practice Guideline on Informed Consent—Radiation Oncology.6

4. Treatment—The procedure and follow-up should be performed according to an established system of procedural steps that may be unique for each type of application.

5. Female patients should not be pregnant, breast-feeding, or lactating at the time radiopharmaceutical therapy is orally, intravenously, or intraperitoneally administered. Pregnancy should be ruled out by a negative human chorionic gonadotropin test obtained prior to administration of the radiopharmaceutical or by documented history of hysterectomy or by a postmenopausal state with absence of menstrual bleeding for 2 years, or by premenarche in a child aged 10 or younger. Breast-feeding should be completely discontinued prior to the therapy and should not be resumed until subsequent pregnancy. Other national regulatory bodies may have similar recommendations. In addition, postpartum lactating patients should not undergo treatment, even if not breast-feeding, for a period of at least 3 months, or until lactation ceases, because the lactating breasts may accumulate significant amounts of iodine-131 or other unsealed therapeutic radiopharmaceuticals, resulting in a significant radiation dose to the patient's breasts. The treating physician should also bear in mind that the immediate postlactating breast may still concentrate iodine-131, resulting in breast radiation dose.

6. Radiation precautions—Radiation precautions and patient release criteria may be regulated federally by the NRC in many states, or by the state (with regulations that are closely patterned on the federal regulations and may be more restrictive). The radiation safety officer, medical physicist, or health physicist for the local facility can provide information on the applicable regulations. Details on the federal regulations can be obtained at the NRC web site, or by telephone (301–415–7000).

Under the guidelines of federal code 10 CFR 35.757 and NRC Regulatory Guide 8.39,8 the patient may be released if the total effective dose equivalent to any other individual who is exposed to the patient is not likely to exceed 5 mSv (0.5 rem), assuming all other regulatory requirements for patient instructions and record keeping are met. NUREG-1556, Vol 9, “Consolidated Guidance about Materials Licenses: Program-Specific Guidance about Medical Use Licenses,” describes methods for calculating doses to other individuals and contains tables of activities not likely to cause doses exceeding 5 mSv (0.5 rem). Agreement states may have specific rules and regulations regarding release of patients with significant residual activity.

Most radiation meters measure exposure rates in milliroentgens/h (mR/h). For low-linear energy transfer rate radiation (including beta particles and most x-rays and gamma rays), the exposure rate in mR/h will be equivalent to the dose rate in 0.01 mSv/h (1 mrem/h). Thus, an exposure rate of 7.0 mR/h at 1 meter is assumed to give a dose rate of 0.07 mSv/h (7.0 mrem/h).

For treatments outside the United States, regulations of the corresponding national regulatory bodies may apply, and all applicable laws and regulations must be followed.

If confinement in a healthcare facility is needed, it is not usually necessary to store body effluents such as urine, stool, or vomitus. For effluent disposal the toilet should be flushed 2 or 3 times after each use to ensure sufficient dilution of radioactivity. Food trays and linens should be stored in the room until monitored and cleared by radiation safety staff. All routine blood work and laboratory specimens should be obtained prior to treatment with the radiopharmaceutical. The patient must stay in the room except in a medical or nonmedical (eg, fire) emergency, and access by personnel and visitors must be limited. All trash and residual nondisposable items must be monitored after the patient's release and stored until radiation levels reach the statutory level defined for safe disposal or reuse. Once all known contamination is removed from the room, the room must be surveyed to verify that the radiation levels are sufficiently low to permit its general use. The room may not be used until this survey is performed.

If the admitting physician is different from the physician who administers the radio-pharmaceutical, there must be a mechanism to prevent premature discharge or release of the patient from confinement.

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B. Iodine-131 (Sodium Iodide) Therapy for Hyperthyroidism

The basic disease entities treated are diffuse toxic goiter (Graves disease), toxic nodular goiter, and solitary toxic nodule (Table 1).

Table 1
Table 1
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1. Diffuse toxic goiter

a. Patient—A recent radioiodine thyroid uptake should be available (mentioned in the ACR–SNM–SPR Practice Guideline for the Performance of Thyroid Scintigraphy and Uptake Measurements9). The size of the thyroid gland should be noted. Optimally, the patient's system should be free of iodide-containing medications, iodinated contrast agents, exogenous thyroid hormone, and antithyroid medications. The patient should avoid food containing very large amounts of iodine for the week prior to therapy; however, a strict low-iodine diet is usually unnecessary.

b. Administered activities—Initial activity of 1.85 to 7.4 MBq (50–200 μCi) per gram of thyroid (after adjusting for current 24-hour radioiodine uptake) may be administered. Generally, the likelihood of residual hyperthyroidism is greater for lower administered activity, and the likelihood of hypothyroidism is greater for higher administered activity. There are also data to support empiric adult dosing with a “fixed” dose of 185 to 555 MBq (5–15 mCi). The measurement of radioiodine uptake before radioiodine therapy is necessary even when a fixed dose is planned, to prevent the inappropriate administration of radioactive iodine. Each treating physician, often in consultation with the referring physician, should decide on an appropriate activity to be administered (section VI.A.6 for radiation precautions).

c. Side effects/complications—Side effects are usually minor. Patients may occasionally experience neck tenderness and/or odynophagia from radiation thyroiditis. Serious complications are rare. However, on occasion, patients with severe hyperthyroidism may experience exacerbation of symptoms within the first 2 weeks following iodine-131 therapy. These symptoms usually respond to short-term beta-blocker therapy, but rarely may progress to frank thyroid storm. Patients should be instructed to contact their referring physician or seek immediate medical care should such symptoms occur. Hypothyroidism is often considered to be a likely or even desired outcome of successful therapy for Graves' disease or toxic nodular goiter and can occur within the first few months following therapy or even decades later, with a small, ongoing annual incidence. Hypothyroidism is treated with carefully monitored hormone replacement therapy. Based on previous multicenter trials, there is no evidence of increased risk of thyroid carcinoma or other malignancy, infertility, or increased incidence of birth defects following iodine-131 therapy for hyperthyroidism.

d. Ideally, patients should not receive thioamide medications (eg, propylthiouracil or methimazole) for at least 5 to 7 days prior to therapy.

e. Subsequent therapies—In patients who have not adequately responded to prior iodine-131 therapy, subsequent treatments may be given. An equal or higher treatment dose is generally used for retreatment. Dose considerations should balance the total activity against the relative risks of residual disease versus hypothyroidism. Repeat therapies are usually not indicated until at least 3 months after a radioiodine treatment to allow the assessment of the effect of therapy.

2. Toxic Nodular Goiter and Solitary Toxic Nodule

a. Patient—mentioned in section VI.B.1.a.

b. Administered activity—These conditions tend to be more resistant to radioiodine therapy. Activity of up to 1.11 GBq (30 mCi) or more for outpatient treatment may be administered, provided that the radioiodine uptake is sufficient.

c. Prior thionamide therapy—the effect of thionamide on the responsiveness of the thyroid to radioiodine therapy is similar to that in diffuse toxic goiter. The treating physician should consider having the patient discontinue the medication to allow for systemic clearance or, if this is not feasible, using an activity in the upper end of the administered activity range.

d. Side effects/complications—mentioned in section VI.B.1.c. If a solitary toxic nodule has fully suppressed the function of the remaining thyroid, the risk of resulting hypothyroidism is decreased, but hypothyroidism may still occur.

e. Treatment failures—Rarely, it may be necessary to administer an activity larger than 1.22 GBq (33.0 mCi) (section VI.A.6).

f. In rare cases, radioiodine therapy may be indicated in other nonsurgical patients with benign thyroid disease.

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C. Iodine-131 (Sodium Iodide) for Ablation of Postoperative Thyroid Remnant and for Therapy for Iodine-Avid Thyroid Cancer

Iodine-avid thyroid cancers frequently take up radioiodine in the absence of significant amounts of residual normal thyroid tissue. To optimize ablative radioiodide therapy for residual or metastatic disease, or in selected cases to facilitate the follow-up for patients with good prognosis, the thyroid remnant should be eliminated by surgery and/or radioiodine treatment, if possible. In planning therapy for a suspected thyroid remnant or metastasis, a total body iodine scan with iodine-123 or iodine-131 may be of assistance in assessing extent of disease.

1. Ablation of Thyroid Remnant

a. Patient—The serum thyroid-stimulating hormone (TSH) must be elevated, usually to a level in excess of 30 μIU/mL, either by withholding oral thyroid hormone to induce endogenous TSH secretion or by injecting recombinant human TSH (rhTSH) to raise the patient's blood level of this hormone before therapy. If a remnant is suspected, thyroid scintigraphy with iodine-131 or iodine-123 may be performed to determine how avidly the thyroid remnant is accumulating radioiodide. If a large thyroid remnant is present, performing a completion thyroidectomy before the iodine-131 therapy should also be considered. Documentation of an elevated TSH level as well as adherence to a low iodine diet for 1 to 2 weeks prior to treatment is recommended. Optimally, the patient's system should be free of iodide-containing medications, iodinated contrast agents, exogenous thyroid hormone, and antithyroid medications. No age limits apply. Administration of more than 74 to 185 MBq (2–5 mCi) of iodine-131 may interfere with subsequent uptake of iodine-131 for several days to several weeks. This “stunning” effect, if it occurs, may be minimized by administering the therapeutic dose shortly after the diagnostic radionuclide dosage.

b. Administered activity—Activities of 1.11 to 3.7 GBq (30–100 mCi) of iodine-131 (sodium iodide) administered orally are most often used. Higher doses may be used for more extensive disease. Prior to administration, the patient should be fasting and should abstain from eating for at least 2 hours after taking an oral dose. The patient may need to be placed on radiation precautions (section VI.A.6 for radiation precautions).

c. Side effects/complications—Side effects include radiation dysphagia and sialadenitis, both of which are activity related and self-limited. To address sialadenitis, measures may be taken to maintain a high level of hydration and stimulate saliva flow following therapy, such as recommending administration of a sialogogue or other agent that stimulates the salivary gland for as long as 6 days.10 With larger activities or multiple administrations, xerostomia may rarely occur. Patients given 3.7 GBq (100 mCi) or more may develop mild treatment-related symptoms such as headache, nausea, and vomiting that begin about 4 hours after iodine-131 administration and resolve within 72 hours. Diarrhea has occasionally been noted. A single dose of 1.85 to 3.7 GBq (50 to 100 mCi) may deliver sufficient radiation to the testes to cause transient testicular failure of uncertain long-term consequence. Discussion of fertility issues should be considered, particularly in young patients who may need multiple treatments. There is some evidence that female fertility may be decreased after activities in excess of 22.2 GBq (600 mCi). Transient myelosuppression may occur with oral doses of iodine-131 in excess of 5.55 to 7.4 GBq (150–200 mCi), and dosimetry is suggested when such doses are used, especially in older patients. Leukemogenesis and carcinogenesis (salivary glands, kidney, bladder, and gastrointestinal tract) have been described in patients following very high dose iodine-131 therapy, ie, 11.1 to 14.8 GBq (300–400 mCi).

2. Known or suspected residual thyroid cancer

a. Patient—mentioned in section VI.B.1.a. An elevated thyroglobulin level or a whole-body survey performed with iodine-131, iodine-123, FDG PET, or other radiopharmaceuticals that show abnormal concentration of tracer indicates recurrence (given in the ACR–SNM–SPR Practice Guideline for the Performance of Thyroid Scintigraphy and Uptake Measurements9).

b. Administered activity—For residual tumor in the thyroid bed without evidence of distant metastasis, activities of 3.7 to 5.55 GBq (100–150 mCi) are usually administered. Complications, side effects, and radiation precautions are similar to those described in section VI.C.1.c.

3. Distant metastases

a. Patient—mentioned in section VI.C.1.a.

b. Activities of 3.7 to 9.25 GBq (100–250 mCi) are usually administered. Complications, side effects, and radiation precautions are similar to those described in sections VI.A.6 and VI.B.1.c. Activity administered can be based on fixed doses, depending on the clinical situation, or based on quantitative iodine-131 dosimetry. Dosimetry calculations of dose to the whole blood and of total lung activity at 48 hours should be considered when the highest activities are used. When larger activities are administered, bone marrow suppression becomes a concern. There are reports of pulmonary fibrosis and/or pneumonitis resulting from therapy for widespread lung metastases when the administered activity delivers a dose of 6 Sv (600 rem) or more to the lung. Pulmonary function studies should be considered prior to treatment if there are widespread pulmonary metastases.

c. After successful remnant ablation, a measurable serum thyroglobulin level suggests functioning iodine avid tissue, the possibility of recurrent disease, and may be an indication for additional treatment. However, both high and low thyroglobulin levels are unreliable in the presence of antithyroglobulin antibodies. In particular, falsely low thyroglobulin levels may occur in antibody-positive patients; therefore, antibody assays should accompany all thyroglobulin measurements. Even when a diagnostic whole-body scan is negative, if the stimulated thyroglobulin level is greater than about 10 ng/mL or there is other evidence of disease, empiric therapy with 3.7 to 5.55 MBq (100–150 mCi) can be considered.

d. In the setting of a negative whole-body scan and suspected metastatic disease, an FDG PET/CT scan may be helpful to localize recurrent/metastatic disease that would potentially be amenable to surgical management.

4. Interactions with other forms of treatment

a. Patients with a high risk of local/regional recurrent disease may be treated with both iodine-131 and external beam irradiation. The use of external beam irradiation prior to or alternating with radioactive iodine treatment has not been shown to be associated with a subsequent reduction in tumor uptake of radioactive iodine. Therefore, external beam irradiation, if indicated, need not be delayed. The toxicity, acute and late, is likely to be additive within the field of irradiation. Dosimetry calculations should be considered if iodine-131 therapy and external beam radiotherapy are both being considered or have previously been performed in patients with spinal lesions, to avoid potential radiation-induced spinal cord damage.

b. Distant metastatic lesions that are painful or are a threat to life or function may be treated with external beam irradiation or surgery in addition to iodine-131.

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D. Strontium-89 and Samarium-153 Lexidronam Therapy for Bone Pain Caused by Skeletal Metastases

1. Patient—Patients with multiple osseous metastases that show increased tracer uptake on bone scintigraphy, who are obtaining diminishing relief from other methods of pain management (eg, analgesics, bisphosphonates, external beam irradiation), and whose bone marrow is competent, are candidates for radiopharmaceutical therapy.11 Complete blood cell count with platelets should be obtained within 7 days prior to therapy. Platelet count should be greater than 60,000 to 100,000/μL, leukocyte count greater than 2400 to 5000/μL, and absolute granulocyrte count greater than 2000/μL. Patients with disseminated intravascular coagulation must be excluded from the therapy. Patients should have an expected life span of greater than 3 months. Others may be treated after a case-by-case evaluation as adjuvant therapy to delay symptomatic skeletal metastases. Urinary incontinence is not a contraindication to treatment, although the patient or caregiver should be instructed on how to minimize radiation contamination from spilled urine. For samarium-153 lexidronam and strontium-89, bladder catheterization should be considered for patients incontinent of urine, to minimize the risk of radioactive contamination.

2. Administered activity—For strontium-89, the standard activity is 1.48 to 2.22 MBq (40–60 μCi per kilogram of body weight, approximately 4 mCi [148 MBq] for standard weight) given by intravenous infusion over several minutes. The recommended samarium-153 lexidronam activity is 37.0 MBq (1.0 mCi) per kilogram of body weight, given intravenously, also over several minutes. When samarium-153 lexidronam is used, whole-body gamma camera imaging may also be performed between 2 and 24 hours postinjection.

3. Complications—A “flare” phenomenon occurs in some patients, with transient worsening of pain within several days after treatment. This is a self-limited process, although it can be severe. Patients should be counseled concerning the possibility of a flare phenomenon. The pain associated with the flare phenomenon can usually be managed with analgesics or steroidal medication. For intravenously administered radiotherapy, extravasation of the radio-pharmaceutical should be avoided. It is imperative to have excellent intravenous access that is confirmed prior to injection. Although local skin damage is unusual, some experts believe it is prudent to follow a vesicant protocol for radiotherapy infusion.12 Bone marrow depression occurs transiently, with a nadir at about 3 to 6 weeks and with recovery in about 3 to 6 additional weeks. Complete blood and platelet counts should be followed routinely for 8 to 12 weeks.

4. Interactions with other forms of treatment.

a. Hormone administration need not be discontinued before the administration of radiopharmaceutical therapy, since it does not interfere with the mechanism of action and does not potentiate any side effects.

b. External beam radiation therapy may be used in concert with radiopharmaceutical therapy for local treatment of selected sites, especially those in which pathologic fracture or cord compression might occur. Careful evaluation of complete blood and platelet counts is required when these therapies are combined.

c. The patient should not have received long-acting myelosuppressive chemotherapy for 6 to 8 weeks and other forms of myelosuppressive chemotherapy for at least 4 weeks prior to radiopharmaceutical administration, also because of potential marrow toxicity.

5. Radiation precautions—There are none for strontium-89 as long as the patient is continent of urine and feces. For samarium-153 lexidronam, the patient may be released if the total effective dose equivalent to any other individual who is exposed to the patient is not likely to exceed 5 mSv (0.5 rem) per year. If state or facility regulations are more restrictive, they should be followed.

6. Retreatment—Retreatment may be done if initial treatment fails or symptoms recur. Special attention should be paid to recovery of bone marrow and blood counts. Retreatment may be given after adequate bone marrow recovery occurs, which is typically 2 to 3 months.

7. As with all other forms of therapy with unsealed sources, patient management should be coordinated with clinical services and with other involved parties, especially radiation oncology, if external beam irradiation has been used or is being considered.

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E. Phosphorus-32 (Sodium Phosphate) for Polycythemia Rubra Vera Associated With Thrombocytosis

Phosphorus-32 (sodium phosphate) is approved for treatment of thrombocytosis associated with polycythemia vera. The diagnosis must be confirmed prior to therapy. The activities should be based on body surface area (85 MBq [2.3 mCi] per square meter intravenously) but may be standardized to a dose of 111 to 185 MBq [3.0–5 mCi] intravenously but should not exceed 185 MBq (5.0 mCi). Relapse or failure to respond within 12 weeks may require retreatment with dosages up to 259 MBq (7.0 mCi). Phosphorus-32 should not be given if the platelet count is less than 100,000/μL or the leukocyte count is less than 3000/μL.

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F. Phosphorus-32 (Colloidal Chromic Phosphate) for Malignant Ascites, Pleural Effusion, or as an Adjunct to Treatment of Borderline Ovarian Neoplasms

The usual activity for intracavitary therapy is 222 to 555 MBq (6–15 mCi) in the pleural cavity and 370 to 740 MBq (10–20 mCi) in the peritoneum. The ability of the radiopharmaceutical to spread uniformly throughout the affected cavity should be documented using technetium-99m sulfur colloid (mentioned in the ACR–SNM–SPR Practice Guideline for the Performance of Gastrointestinal Scintigraphy13) as an intraperitoneal or intrapleural injection followed by appropriate imaging. The patient should be turned to distribute the imaging agent. After documented dispersal, ie, no evidence of loculation or penetration into the bowel, the patient may be treated. The combination of intraperitoneal phosphorus-32 colloidal chromic phosphate and external irradiation to the pelvis has been reported to be associated with a high incidence of morbidity, particularly bowel obstruction; accordingly, caution must be observed when this combination of therapies is used.

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G. Yttrium-90 Ibritumomab Tiuxetan and Iodine-131 Tositumomab for Radioimmunotherapy of Non-Hodgkin Lymphoma

1. AgentsYttrium-90 ibritumomab tiuxetan consists of ibritumomab, the murine IgG1 kappa monoclonal antibody from which rituximab was developed, and tiuxetan, which stably chelates indium-111 for imaging and yttrium-90 for therapy. Iodine-131 tositumomab is a murine IgG2a lambda monoclonal antibody covalently linked to iodine-131. Both antibodies are directed against the CD20 antigen which is found on the surface of normal and malignant B lymphocytes.

2. Patient

a. Patients with CD20 positive follicular B-cell non-Hodgkin lymphoma, with or without transformation, including patients who are refractory to rituximab, are candidates for radioimmunotherapy.

b. The principal toxicity of anti-CD20 radioimmunotherapy is hematologic. A careful hematologic evaluation needs to be performed prior to therapy. Since lymphoma in the bone marrow will increase the dose to the marrow, a recent bone marrow biopsy must be evaluated by an experience hematopathologist.

c. Patients should have diagnostic scanning prior to the therapeutic dose delivery to verify individual biodistribution. Indium-111 ibritumomab tiuxetan is used for diagnostic studies prior to treatment with yttrium-90 ibritumomab tiuxetan, and a diagnostic activity of iodine-131 tositumomab is used prior to the therapeutic dose delivery of that radiopharmaceutical. Patients with altered biodistribution as described in section 3 below should not be treated with these radiopharmaceuticals. The pretreatment scans are also used to calculate the therapeutic dose for iodine-131 tositumomab.

d. Patients treated with iodine-131 tositumomab are at risk for hypothyroidism. To reduce this probability, they must be treated with either a saturated solution of potassium iodide 4 drops orally a day, Lugol solution 20 drops orally 3 times a day, or potassium iodide tablets 130 mg orally once a day, starting at least 24 hours prior to initiating the iodine-131 tositumomab dosimetric dose. Thyroid blockade must continue until 2 weeks after administration of the iodine-131 tositumomab therapeutic dose. If the patient is not required to remain in the hospital, he or she may need to receive appropriate counseling concerning limitation of dose to other individuals.

3. Dosimetry and assessment of biodistribution

a. Altered biodistribution is uncommon. Biodistribution is considered to be altered if indium-111 ibritumomab tiuxetan blood pool concentration is not well visualized, indicating rapid clearance by reticuloendothelial system. It can be represented by any of the following conditions: urinary obstruction; diffuse lung uptake greater than that of the blood pool, or intense areas of bowel uptake that is comparable to that of the liver.

b. Patients treated with iodine-131 tositumomab have total body counts and images obtained by gamma camera scanning on day 0 (within 1 hour of administration, before the patient voids), on days 2 to 4, and on day 6 or 7 if necessary. The biodistribution is evaluated with the same criteria used earlier. Total body resident times of less than 50 hours or more than 150 hours represent altered biodistribution. The total body residence time is used as a factor in calculating the dose of iodine-131 tositumomab, which is calculated using a nomogram provided by the manufacturer.

4. Administered activity

a. For both yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab, administration should occur during a specified period of time after the first diagnostic scan.

b. According to manufacturer's instructions, the therapeutic dose of yttrium-90 ibritumomab tiuxetan is administered on days 7 to 9, with day 1 being the day of the first dosimetric scan. Iodine-131 tositumomab administration is recommended to occur on day 7 (up to day 14), with day 0 being the day of the first dosimetric scan.

c. Biodistribution of both diagnostic and therapeutic administration is improved by concurrent administration of unlabeled agents to saturate readily accessible CD20 positive sites, including circulating B-cells and cells in the spleen. Biodistribution of radiolabeled ibritumomab tiuxetan is improved with the prior administration of rituximab. Unlabeled tositumomab is used for this purpose with iodine-131 tositumomab administration.

d. The therapeutic dose for yttrium-90 ibritumomab tiuxetan, after an infusion of rituximab, is 14.8 MBq/kg (0.4 mCi/kg) for patients with a platelet count >150,000 cells/μL and 11.1 MBq/kg (0.3 mCi/kg) for patients with platelet count of 100,000 to 149,000 cells/μL. The maximum allowable dose of yttrium-90 ibritumomab tiuxetan is 1.184 GBq (32.0 mCi).

e. For iodine-131 tositumomab, the administered activity is that calculated to provide a prescribed total body dose of 0.75 Gy (75 rad) for patients with a platelet count >150,000 cells/μL and 0.65 Gy (65 rad) cGy for patients with platelet count of 100,000 to 149,000 cells/μL. Patients should not be treated if the platelet count is <100,000 cells/μL.

f. Since yttrium-90 is a pure beta emitter, on-site administered-dose measurement can be very difficult. A precise technique with careful attention to detail should be established with the help of a radiopharmacist or a medical physicist.

5. Complications

a. Hypersensitivity reactions occur and may be severe. Patients who have received murine proteins should be screened for human antimouse antibodies. Patients who are positive are likely to be at increased risk of anaphylaxis and serious hypersensitivity and may show altered biodistribution of the antibody. Known hypersensitivity to rituximab or murine proteins is considered a contraindication to administration of yttrium-90 ibritumomab tiuxetan. Premedication with acetaminophen and diphenhydramine is recommended and should be considered prior to diagnostic and therapeutic infusions. Reactions to the unlabeled antibody infusion of rituximab or unlabeled tositumomab are common. Although reactions to subsequently infused iodine-131 tositumomab or indium-111 or yttrium-90 ibritumomab tiuxetan are uncommon, a physician must be present. Medications for the treatment of hypersensitivity reactions (eg, epinephrine, antihistamines, and corticosteroids) and equipment for resuscitation should be immediately available.

b. The most common serious adverse reactions associated with both yttrium-90 ibritumomab tiuxetan and iodine-131 tositumomab are severe or life-threatening cytopenias. With yttrium-90 ibritumomab tiuxetan, approximately 85% of patients are expected to experience grade 3 or 4 cytopenia. Cytopenias are influenced by initial bone marrow reserve as evidenced by baseline platelet count. With iodine-131 tositumomab, 71% of 230 patients enrolled in clinical studies experienced grade 3 or 4 cytopenias. The nadir can occur from 1 to more than 3 months after administration, and the duration of cytopenias can be from 3 to 5 weeks. Precautions include not treating patients who have more than 25% of bone marrow involved, or who have poor bone marrow reserve (including but not limited to prior stem-cell or bone marrow transplant, absolute neutrophil count <1500 cells/μL, or previous failure of stem cell collection). The dose is modified according to the pretreatment platelet counts. Blood counts are monitored weekly or more frequently as needed until recovery occurs, for at least 10 to 12 weeks. Stem cell support and/or transfusions are provided as necessary, and cases of febrile neutropenia or infection are treated as appropriate.

c. In patients treated with iodine-131 tositumomab, hypothyroidism occurs approximately 5% of the time, despite thyroid protection.

6. Interactions with other forms of treatment

a. A time interval sufficient to allow for bone marrow recovery after cytotoxic chemotherapy is recommended. Concomitant use of chemotherapy with yttrium-90 ibritumomab tiuxetan or iodine-131 tositumomab therapy has not been fully evaluated and should be considered with caution when not performed in conjunction with a defined research protocol.

b. Prior to radiopharmaceutical therapy, external beam radiation therapy may be necessary for local treatment of selected sites, especially when life-threatening or function-threatening involvement such as fracture or spinal cord compression exists or is likely to occur without such treatment. Careful consideration must be given to the amount of bone marrow treated, as treatment of a large percentage of the patient's bone marrow is likely to significantly affect the ability to tolerate radioimmunotherapy.

7. Radiation precautions

a. Lead shielding is used for the storage and handling of radiolabeled indium-111 (a gamma emitter), a required injection before yttrium-90. For yttrium-90 ibritumomab tiuxetan, there are no special precautions, beyond the usual care taken to minimize radiation exposure to patients and to medical personnel, consistent with institutional radiation safety practices and patient management procedures. Yttrium-90 is a pure beta emitter, and safety precautions for medical professionals are universal precautions, with the addition of acrylic shielding for the yttrium-90 ibritumomab tiuxetan. Patients may be released immediately, with basic instructions, after administration of yttrium-90 ibritumomab tiuxetan.

b. Iodine-131 tositumomab is both a beta and a gamma emitter, and lead shielding is required during storage, preparation, and administration. Under the guidelines of federal code 10 CFR 35.75, the patient may be released if the total effective dose equivalent to any other individual who is exposed to the patient is not likely to exceed 5 mSv (0.5 rem), assuming all other regulatory requirements for patient instructions and record keeping are met. Assessment includes a calculation based on the patient's measured total body residence time (a function of the antibody clearance rate) and dose rate at 1 meter, as well as the individual's living and working situation and ability to comply with instructions. If state or facility regulations are more restrictive, they should be followed.

8. As with all other forms of therapy with unsealed sources, patient management should be coordinated with clinical services and with other involved parties, especially medical and radiation oncology.

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H. Follow-up After Treatment

Physicians using unsealed radiopharmaceutical sources for therapy should participate with the patient's primary physician in the follow-up and management of all patients treated with curative, adjuvant, or palliative intent and should document the outcome of therapy, including results of treatment (tumor control, survival, degree of palliation, time to retreatment) and significant sequelae.11

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Reporting should be in accordance with the ACR Practice Guideline for Communication: Radiation Oncology.14

The report should include the radiopharmaceutical used and the dose and route of administration, as well as any other pharmaceuticals administered, also with dose and route of administration.

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It is the position of the ACR that both nuclear medicine physicians and radiation oncologists are particularly well qualified by training and experience to administer unsealed radiopharmaceutical sources for treatment and that either can do so independently. Often, the preferred approach is for the nuclear medicine physician and radiation oncologist to work together as a physician team. The approach that is chosen may vary from patient to patient depending on the type of cancer being treated, local expertise, and patient-related issues. Whichever approach is used, it is important that patient selection as well as overall treatment planning and follow-up be performed by physicians with training and expertise in cancer management, basic radiation safety, and radiation physics.

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Radiologists, imaging technologists, and all supervising physicians have a responsibility to minimize radiation dose to individual patients, to staff, and to society as a whole, while maintaining the necessary diagnostic image quality. This concept is known as “as low as reasonably achievable.”

Facilities, in consultation with the radiation safety officer, should have in place and should adhere to policies and procedures for the safe handling and administration of radiopharmaceuticals, in accordance with as low as reasonably achievable, and must comply with all applicable radiation safety regulations and conditions of licensure imposed by the NRC and by state, and/or other regulatory agencies. Quantities of radiopharmaceuticals should be tailored to the individual patient by prescription or protocol.

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Policies and procedures related to quality control and improvement, patient education, infection control, and safety should be developed and implemented in accordance with the ACR Policy on Quality Control and Improvement, Safety, Infection Control, and Patient Education appearing under the heading Position Statement on QC & Improvement, Safety, Infection Control, and Patient Education on the ACR web page (

Equipment performance monitoring should be in accordance with the ACR Technical Standard for Medical Nuclear Physics Performance Monitoring of Gamma Cameras.

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This guideline was revised according to the process described under the heading “The Process for Developing ACR Practice Guidelines and Technical Standards” on the ACR web page ( by the Guidelines and Standards Committee of the Commission on Radiation Oncology in collaboration with the ASTRO and with the cooperation of the ABS.

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1. ACR technical standard for diagnostic procedures using radiopharmaceuticals. Practice Guidelines and Technical Standards. Reston, VA: American College of Radiology; 2008:1203–1209.

2. Federal Drug Administration. Supplement Approval Letter (Zevalin). Available at: Accessed October 29, 2009.

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6. ACR practice guideline on informed consent—radiation oncology. Practice Guidelines and Technical Standards. Reston, VA: American College of Radiology; 2008:937–941.

7. United States Nuclear Regulatory Commission. § 35.75 release of individuals containing unsealed byproduct material or implants containing byproduct material, 2007. Available at:–0075.html. Accessed March 18, 2009.

8. United States Nuclear Regulatory Commission. Regulatory guide 8.39, release of patients administered radioactive materials, 1997. Available at: Accessed March 18, 2009.

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11. Schraml FV, Parr LF, Ghurani S, et al. Autopsy of a cadaver containing strontium-89-chloride. J Nucl Med. 1997;38:380–382.

12. Williams G, Palmer MR, Parker JA, et al. Extravasation of therapeutic yttrium-90-ibritumomab tiuxetan (zevalin): a case report. Cancer Biother Radiopharm. 2006;21:101–105.

13. ACR practice guideline for the performance of gastrointestinal scintigraphy. Practice Guidelines and Technical Standards. Reston, VA: American College of Radiology; 2008:863–870.

14. ACR practice guideline for communication: radiation oncology. Practice Guidelines and Technical Standards. Reston, VA: American College of Radiology; 2008:931–936.

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SUGGESTED READING (Additional articles that are not cited in the document but that the committee recommends for further reading on this topic).

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unsealed sources; radiopharmaceutical; iodine-131; phosphorous-32; radionuclide therapy; yttrium-90; samarium-153; strontium-89

© 2011 Lippincott Williams & Wilkins, Inc.


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