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Kidney Tumor in a von Hippel-Lindau (VHL) Patient With Intensely Increased Activity on 68Ga-DOTA-TATE PET/CT

Papadakis, Georgios Z. MD, MPH; Millo, Corina MD; Sadowski, Samira M. MD; Bagci, Ulas PhD; Patronas, Nicholas J. MD

doi: 10.1097/RLU.0000000000001393
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Renal and pancreatic cysts and tumors are the most common visceral manifestations of von Hippel-Lindau (VHL) disease, a heritable multisystem cancer syndrome characterized by development of a variety of malignant and benign tumors. We report a case of a VHL patient with multiple renal cystic and complex cystic/solid lesions. The patient underwent 68Ga-DOTA-TATE-PET/CT showing intensely increased activity by a solid lesion which demonstrated enhancement on both CT and MRI scans, raising high suspicion for malignancy. The presented case indicates application of SSTR-imaging using 68Ga-DOTA-conjugated peptides in VHL-patients and emphasizes the need for cautious interpretation of renal parenchyma 68Ga-DOTATATE activity.

From the *Radiology and Imaging Sciences, Warren Grant Magnuson Clinical Center (CC), National Institutes of Health (NIH), Bethesda; †Division of Nuclear Medicine, RAD&IS, Clinical Center, National Institutes of Health (NIH), Bethesda; †Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; §Endocrine and Thoracic Surgery, University Hospitals of Geneva, Geneva, Switzerland; and ∥Center for Research in Computer Vision (CRCV), Electrical and Computer Science Department, University of Central Florida (UCF), Orlando, FL.

Received for publication May 12, 2016; revision accepted August 16, 2016.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Nicholas J. Patronas, MD, Neuroradiology Branch, Warren Grant Magnuson Clinical Center (CC), National Institutes of Health (NIH), Bldg 10, Room 1C361X 10 CENTER DR, Bethesda, MD 20814 (Mail stop 1182). E-mail: NPatronas@cc.nih.gov.

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