Skip Navigation LinksHome > May 2014 - Volume 39 - Issue 5 > The Ratio of 18F-FDG Activity Uptake Between the Right and L...
Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000422
Original Articles

The Ratio of 18F-FDG Activity Uptake Between the Right and Left Ventricle in Patients With Pulmonary Hypertension Correlates With the Right Ventricular Function

Yang, Tao MD; Wang, Lei MD; Xiong, Chang-Ming MD; He, Jian-Guo MD; Zhang, Yan MD; Gu, Qing MD; Zhao, Zhi-hui MD; Ni, Xin-Hai MD; Fang, Wei MD; Liu, Zhi-Hong MD

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Abstract

Purpose

It is known that patients with pulmonary hypertension (PH) can have elevated 18F-FDG uptake in the right ventricle (RV) on PET imaging. This study was designed to assess possible relationship between FDG uptake of ventricles and the function/hemodynamics of the RV in patients with PH.

Patients and Methods

Thirty-eight patients with PH underwent FDG PET imaging in both fasting and glucose-loading conditions. The standard uptake value (SUVs) corrected for partial volume effect in both RV and left ventricle (LV) were measured. The ratio of FDG uptake between RV to LV (SUVR/L) was calculated. Right heart catheterization and cardiac magnetic resonance (CMR) were performed in all patients within 1 week. The FDG uptake levels by the ventricles were compared with the result form the right heart catheterization and CMR.

Results

The SUV of RV (SUVR) and SUV of LV were significantly higher in glucose-loading condition than in fasting condition. In both fasting and glucose-loading conditions, SUVR and SUVR/L showed reverse correlation with right ventricular ejection fraction derived from CMR. In addition, in both fasting and glucose-loading conditions, SUVR and SUVR/L showed positive correlations with pulmonary vascular resistance. However, only SUVR/L in glucose-loading condition could independently predict right ventricular ejection fraction after adjusted for age, body mass index, sex, mean right atrial pressure, mean pulmonary arterial pressure, and pulmonary vascular resistance (P = 0.048).

Conclusions

The FDG uptake of RV increases with decreased right ventricular function in patients with PH. Increased FDG uptake ratio between RV and LV might be useful to assess the right ventricular function.

Copyright © 2014 by Lippincott Williams & Wilkins

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