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Peptide Receptor Radionuclide Therapy With 177Lu DOTATATE in a Case of Recurrent Carotid Body Paraganglioma With Spinal Metastases

Gupta, Santosh Kumar MSc; Singla, Suhas MD; Karunanithi, Sellam MD; Damle, Nishikant MD; Bal, Chandrasekhar MD, DSc (HC)

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000273
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Abstract: Paragangliomas are rare benign neuroendocrine tumors, and 80% of all paragangliomas are either carotid body tumors or glomus jugulare tumors. We present a case of recurrent unresectable carotid body paraganglioma with nodal and T7 vertebral metastases in a 30-year-old man 6 years postsurgery detected with 68Ga DOTANOC PET/CT and was administered with peptide receptor radionuclide therapy using 177Lu DOTATATE. After 5 cycles of 177Lu DOTATATE (total cumulative activity of 750 mCi [27 GBq]), significant response at the primary site on 68Ga DOTANOC PET/CT and complete disappearance of nodal and T7 vertebral metastases were noted.

Author Information

From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Received for publication January 30, 2013; revision accepted September 03, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Chandrasekhar Bal, MD, DSc (HC), Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India. E-mail:

© 2014 by Lippincott Williams & Wilkins