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Lymphoma as a Second Malignancy in a Patient With Neuroendocrine Tumor: Mimicking Dedifferentiation on Dual-Tracer PET/CT With 68Ga-DOTANOC and 18F-FDG

Jain, Sachin MD; Sharma, Punit MD; Dhull, Varun Singh MD; Bal, Chandrasekhar MD; Kumar, Rakesh MD, PhD

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e31828e98c5
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Abstract

Abstract: Neuroendocrine tumors (NETs) are rare tumors which express somatostatin receptors (SSTRs). We here present a case of a 50-year-old female patient with metastatic bronchial carcinoid. She underwent 68Ga-DOTANOC PET/CT and 18F-FDG PET/CT which suggested a diagnosis of poorly differentiated NET. Biopsy of the lesion, however, revealed a second malignancy in the form of diffuse large B-cell lymphoma. Thus, very rarely, other primary tumors can mimic NETs on dual-tracer PET/CT, and biopsy is advised in doubtful cases.

Author Information

From the Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Received for publication November 28, 2012; and revision accepted February 21, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Rakesh Kumar, MD, PhD, E-81, Ansari Nagar (East), AIIMS Campus, New Delhi 110029, India. E-mail: rkphulia@yahoo.com.

© 2014 by Lippincott Williams & Wilkins