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Diffuse Renal Parenchyma Uptake With Bone Scintigraphy in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Normal Kidney Function

Balink, Hans MD*; Hoogendoorn, Mels MD, PhD; Hemmelder, Marc MD, PhD

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000333
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Abstract: A 41-year-old woman with a Harrington spondylodesis presented with lower back pain. Bone scintigraphy showed diffusely increased parenchymal uptake in both kidneys. She reported 2 previous periods of dark, almost black, urine. Additional flow cytometric analysis confirmed the diagnosis of paroxysmal nocturnal hemoglobinuria. The increased renal parenchyma uptake is very probably due to paroxysmal nocturnal hemoglobinuria–related renal hemosiderosis. Remarkably, the patient did not develop any abnormality of renal function.

Author Information

From the Departments of *Nuclear Medicine, †Hematology, and ‡Nephrology, Medical Center Leeuwarden, Leeuwarden, the Netherlands.

Received for publication March 15, 2013; revision accepted November 19, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Hans Balink, MD, Medical Center Leeuwarden, PO Box 850, 8901 BR Leeuwarden, the Netherlands. E-mail:

© 2014 by Lippincott Williams & Wilkins