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Biological Target Volume Overlapping Segmentation System Method for Avoiding False-Positive PET Findings in Assessing Response to Neoadjuvant Chemoradiation Therapy in Rectal Cancer

Maffione, Anna Margherita MD*; Chondrogiannis, Sotirios MD*; Marzola, Maria Cristina MD*; Rampin, Lucia MD*; Grassetto, Gaia MD*; Ferretti, Alice MD; Bellan, Elena MD; Capirci, Carlo MD; Colletti, Patrick M. MD§; Rubello, Domenico MD*

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000265
Original Articles
Abstract

Purpose: FDG PET/CT has a recognized high predictive power to assess the response to neoadjuvant chemoradiation therapy (CRT) in patients affected by locally advanced rectal cancer (LARC), but a relatively high number of false-positive findings decrease its specificity: with the aim to solve this problem, a new method of imaging analysis is here proposed.

Methods: The new method here described, named Biological target volume (BTV) Overlapping Segmentation System (BOSS), has been applied on 24 consecutive patients with LARC that were all previously classified as nonresponders to CRT by means of the response index criterion that is adopted in our center. The BOSS method is based on the quantification of the amount of superimposition between pretreatment and posttreatment BTV. All BTVpre was down using a threshold of 60% of SUVmax in the tumor (BTV60). The results (overlap volumes and percentage of overlap volumes) were then matched up with postoperative pathology classified by the Mandard’s tumor regression grade (TRG) system.

Results: Eleven patients were classified as responders (TRG1–2) and 13 as nonresponders (TRG 3–5). Among all the results obtained by BOSS method, only the percentage of overlap volume data between BTV60 and BTVpost (%Over_60) was able to correctly distinguish between responders and nonresponders. In our experience, a cutoff of 56% on the %Over_60 provided the best results in terms of true negative (11 cases), true positive (12 cases), false negative (1 case), and false positive (none).

Conclusions: This new method, we developed, appears able to unmask the false-positive cases, improving the specificity of FDG PET/CT to predict the response to CRT patients with LARC.

Author Information

*Department of Nuclear Medicine, †Medical Physics Unit, and ‡Department of Radiotherapy & Oncology, Santa Maria della Misericordia Hospital, Rovigo, Italy; and §Department of Radiology, University of Southern California, Los Angeles, CA.

Received for publication July 29, 2013; and revision accepted August 29, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Anna Margherita Maffione, MD, Nuclear Medicine & PET/CT Centre, Santa Maria della Misericordia Hospital, Viale Tre Martiri, 140, 45100 Rovigo, Italy. E-mail: maffionemarghe@libero.it.

© 2014 by Lippincott Williams & Wilkins