Clinical Nuclear Medicine

Skip Navigation LinksHome > February 2014 - Volume 39 - Issue 2 > 18F-Choline PET/CT Pitfalls in Image Interpretation: An Upda...
Clinical Nuclear Medicine:
doi: 10.1097/RLU.0000000000000303
Original Articles

18F-Choline PET/CT Pitfalls in Image Interpretation: An Update on 300 Examined Patients With Prostate Cancer

Calabria, Ferdinando MD*; Chiaravalloti, Agostino MD; Schillaci, Orazio MD*†

Collapse Box


Objectives: 18F-choline PET/CT is an important diagnostic tool in the management of patients with prostate cancer (PC). The aim of this study was to describe and discuss some abnormal sites of uptake that we observed, not due to PC recurrence.

Patients and Methods: Three hundred patients were submitted to 18F-choline PET/CT for staging or restaging of PC. Whole-body PET/CT was acquired 40 minutes after the 18F-choline administration.

Results: We found abnormal uptake of the tracer, not related to PC, in 48/300 patients (16%). Most of these findings were due to inflammatory processes. Furthermore, some malignant conditions, such as a case of colon cancer, a case of bladder carcinoma, and a multiple myeloma, were diagnosed. Mild uptake was also detected in some benign diseases, such as thymoma, adrenal adenoma, and sarcoidosis. Six patients showed focal brain uptake in correspondence to a meningioma.

Conclusions: It is necessary for nuclear physicians, during clinical practice, to consider the possibility of 18F-choline uptake in some benign or malignant conditions for the intrinsic pharmacologic property of the tracer. An accurate medical investigation, correlative imaging with CT and/or MRI with contrast agents, laboratory data, and above all, histologic examination are often necessary for correct diagnosis.

© 2014 by Lippincott Williams & Wilkins


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.