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Granulosa Cell Tumor of the Ovary With High FDG Uptake

Caoduro, Cécile MD*†; Ungureanu, Constantin Marius MD*†; Singeorzan, Cristina Maria MD; Angoue, Orland MD*†; Blagosklonov, Oleg MD, PhD*†; Boulahdour, Hatem MD, PhD*†

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e318292aa65
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Abstract: Granulosa cell tumor (GCT) of the ovary is a rare tumor accounting for 2%–5% of ovarian malignancies. Although the usefulness of 18F-FDG PET/CT is well demonstrated in the staging and follow-up of the great majority of ovarian cancers, GCTs are known to cause false-negative results on FDG PET because of very low FDG avidity. We present a case of a GCT in which an 18F-FDG PET/CT proved very useful in the detection of recurrence.

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From the *University of Franche-Comte, Besançon, †Departments of Nuclear Medicine, and ‡Pathology, University Hospital of Besançon, Besançon, France.

Received for publication August 17, 2012; revision accepted March 10, 2013.

Conflicts of interest and sources of funding: none declared.

Reprints: Caoduro Cécile, MD, Department of Nuclear Medicine, CHU Jean Minjoz, Boulevard Alexandre Fleming, 25030 Besançon, France; E-mail:

© 2013 by Lippincott Williams & Wilkins