Clinical Nuclear Medicine

Skip Navigation LinksHome > July 2013 - Volume 38 - Issue 7 > 11C-Choline PET/CT Scan in Patients With Prostate Cancer Tre...
Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e3182952c4c
Original Articles

11C-Choline PET/CT Scan in Patients With Prostate Cancer Treated With Intermittent ADT: A Sequential PET/CT Study

Ceci, Francesco MD*; Schiavina, Riccardo MD; Castellucci, Paolo MD*; Brunocilla, Eugenio MD; Fuccio, Chiara MD; Colletti, Patrick M. MD§; Ferretti, Alice MSc; Chondrogiannis, Sotirios MD; Rubello, Domenico MD; Romagnoli, Daniele MD; Malizia, Claudio BSc*; Martorana, Giuseppe MD; Fanti, Stefano MD*

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Aim: The purpose of this preliminary study was to evaluate the usefulness of 11C-choline PET/CT in patients with recurrent prostate cancer and hormone-sensitive disease treated with intermittent antiandrogen therapy scheme.

Patients and Methods: We retrospectively evaluated 10 patients after radical prostatectomy (n = 8) or external beam radiotherapy (n = 2) as primary therapy, studied with sequential 11C-choline PET/CT. The first PET/CT (PET1) was performed during antiandrogen therapy (ADT) and the second PET/CT (PET2) was performed after therapy interruption. Only patients with negative results at PET1 were included in the study. At the time of PET1, all patients were under ADT from at least 6 months (mean PSA 0.54 ng/mL). At the time of PET2, all patients had completed ADT for a mean period of 7 months. 11C-Choline PET/CT findings were validated by a follow-up of at least 12 months or histological confirmation in case of local relapse.

Results: PET2 has been able to detect the site of recurrences in all cases. At the time of PET2, mean PSA was 3.88 ng/mL; mean PSAdt was 2.46 months; and mean PSAvel was 6.94 ng/mL/year. Four out of 10 patients showed a single lesion, 5 out of 10 patients showed 2 lesions and 1 patient showed multiple lymph-node lesions.

Conclusion: When performed during ADT interruption, 11C-choline PET/CT has been able to detect the site of recurrence in patients with increasing PSA values. In this context, 11C-choline PET/CT may help to assess the burden of disease or to change the therapeutic approach using more aggressive and addressed therapies like guided RT or salvage lymph-node dissection.

© 2013 by Lippincott Williams & Wilkins


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