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PET/CT Illustration of Metastatic Breast Cancer to the Left Mandibular Foramen

Kota, Gopi MD*; Gupta, Pushpender MD*; Mintz, Akiva MD, PhD*†

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e3182868ae5
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Abstract: Mental nerve neuropathy (numb chin/lip syndrome) is a sensory neuropathy presenting with numbness in the distribution of the inferior alveolar nerve/mental nerve (chin and lower lip). This is typically unilateral and can be secondary to dental disease or malignancy. When caused by malignancy, these symptoms can be either an initial presentation of an unsuspected tumor or progressive metastatic disease, both of which would indicate poor prognosis. We describe a 48-year-old female patient with a history of breast cancer who presented with left chin numbness and manifested a metastatic lesion involving the left mandibular foramen on PET/CT and subsequent MRI.

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From the *Departments of Radiology and †Neurosurgery, Wake Forest School of Medicine, Winston Salem, North Carolina.

Received for publication August 3, 2012; and revision accepted December 29, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Akiva Mintz, MD, PhD, Department of Radiology and Neurosurgery, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. E-mail:

© 2013 by Lippincott Williams & Wilkins