Abstract: Major urologic surgery performed in the lithotomy position sometimes results in the serious complication of rhabdomyolysis. A 56-year-old man was admitted to the hospital for prostate adenocarcinoma. A whole-body bone scan was performed to exclude bony metastases, which demonstrated no bone lesions but showed intense soft-tissue activity in gluteus maximus muscles, findings suggestive of a myopathy. He had just undergone right nerve-sparing radical prostatectomy in the lithotomy position for 6 hours and presented with swollen bilateral thighs. Elevation of creatine kinase level confirmed muscle injury.