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Coronary Endothelial Dysfunction Demonstrated by Means of 15O-Labeled Water PET/CT in Hypothyroid Cardiomyopathy

Legallois, Damien MD*†; Hardouin, Juliette MS; Agostini, Denis MD, PhD*†; Milliez, Paul MD, PhD†§; Manrique, Alain MD, PhD*†∥

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e3182817d13
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Abstract: Hypothyroidism is a rare cause of dilated cardiomyopathy. Triiodothyronine was found to target endothelial nitric oxide synthase, which serves to enhance peripheral vascular relaxation by acting on vascular smooth muscle cells. In patients with subclinical hypothyroidism, adenosine-induced coronary flow reserve is significantly reduced. We report the case of a 46-year-old woman with hypothyroid cardiomyopathy manifested as reversible severe left ventricular dysfunction (LVEF = 32%). 15O-labeled water PET at rest and during cold pressor test showed a severe coronary endothelial dysfunction. In patients with severe hypothyroidism, endothelial function is impaired and may be an important mechanism of heart failure.

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From the *Nuclear Medicine Department, CHU de Caen; †Normandie Université‡Endocrinology Department, §Cardiololgy Department, University Hospital of Caen; and ∥Department of Human Investigations, GIP Cyceron, Caen, France.

Received for publication September 7, 2012; and revision accepted December 4, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Damien Legallois, MD, Nuclear Medicine Department, University Hospital of Caen, 14000 Caen, France. E-mail:

© 2013 by Lippincott Williams & Wilkins