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Comparison of 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT Imaging in Metastasized Merkel Cell Carcinoma

Epstude, Maximilian MD*; Tornquist, Katharina MD*; Riklin, Christian MD; di Lenardo, Francesca MD; Winterhalder, Ralph MD; Hug, Urs MD§; Strobel, Klaus MD*

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e318281658e
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Abstract

Abstract: Merkel cell carcinoma (MCC) is a rare but very aggressive neuroendocrine tumor of the skin in elderly patients with higher mortality compared with melanoma. No evidence-based standardized chemotherapy exists for metastasized patients.

We report the case of an 87-year-old patient with the history of resection of a large MCC of the parietal scalp planned for radiotherapy and staged with FDG PET/CT showing disseminated distant metastases. 68Ga-DOTATATE PET/CT revealed more extensive tumor load compared with FDG, and due to the intensive expression of somatostatin receptors the patient qualified for 90Y DOTATOC therapy.

Author Information

From the *Departments of Nuclear Medicine and Radiology, †Oncology, ‡Radiation Oncology, and §Hand and Plastic Surgery, Cantonal Hospital Lucerne, Lucerne, Switzerland.

Received for publication August 21, 2012; and revision accepted November 18, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Klaus Strobel, MD, Department of Nuclear Medicine and Radiology, Cantonal Hospital Lucerne, CH 6000 Lucerne 16, Switzerland. E-mail: klaus.strobel@luks.ch.

© 2013 by Lippincott Williams & Wilkins