Purpose: The study aimed to evaluate the efficacy of PET/CT in detecting peritoneal carcinomatosis in patients with ovarian cancer and to compare the diagnostic accuracy of FDG PET/CT with that of enhanced abdominal CT.
Methods: The medical records of 46 consecutive patients with ovarian cancer were reviewed, and the presence of peritoneal tumor on 18F-FDG PET/CT and enhanced abdominal CT scans was also assessed. Imaging results were compared with the pathologic findings obtained by surgery.
Results: Pathologic results were positive for peritoneal carcinomatosis in 26 patients and negative in 20 patients. PET/CT correctly detected 25 of 26 patients with peritoneal carcinomatosis and enhanced abdominal CT correctly detected 23 of 26 patients. Sensitivity and specificity for the diagnosis of peritoneal carcinomatosis were 96.2% and 90%, respectively, for PET/CT and 88.5% and 65%, respectively, for enhanced abdominal CT. The accuracy of PET/CT was statistically higher than that of enhanced abdominal CT (93.5% vs 78.3%, P = 0.039). Four distinctly abnormal PET/CT findings of single nodular, multiple nodular, diffuse, and mixed FDG uptakes were identified and corresponded to pathologic findings.
Conclusions: 18F-FDG PET/CT imaging is efficient in the diagnosis of peritoneal carcinomatosis and its performance is superior to that of enhanced abdominal CT.
From the *Department of Nuclear Medicine, Keimyung University School of Medicine, Daegu; †Kyungpook National University School of Medicine, Kyungpook, South Korea; and ‡Daegu, South Korea and University of Texas-Health Science Center, Houston, TX.
Received for publication January 5, 2012; revision accepted May 23, 2012.
Conflicts of interest and sources of funding: none declared.
Reprints: Kyoung Sook Won, MD, PhD, Department of Nuclear Medicine, Keimyung University, School of Medicine, 194 Dongsan-Dong, Jung-Gu, Daegu, South Korea. E-mail: email@example.com.