Clinical Nuclear Medicine

Skip Navigation LinksHome > February 2013 - Volume 38 - Issue 2 > Peritoneal Carcinomatosis in Patients With Ovarian Cancer: E...
Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e31826390ec
Original Articles

Peritoneal Carcinomatosis in Patients With Ovarian Cancer: Enhanced CT Versus 18F-FDG PET/CT

Kim, Hae Won MD*; Won, Kyoung Sook MD, PhD*; Zeon, Seok Kil MD, PhD*; Ahn, Byeong-Cheol MD, PhD; Gayed, Isis W. MD

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Abstract

Purpose: The study aimed to evaluate the efficacy of PET/CT in detecting peritoneal carcinomatosis in patients with ovarian cancer and to compare the diagnostic accuracy of FDG PET/CT with that of enhanced abdominal CT.

Methods: The medical records of 46 consecutive patients with ovarian cancer were reviewed, and the presence of peritoneal tumor on 18F-FDG PET/CT and enhanced abdominal CT scans was also assessed. Imaging results were compared with the pathologic findings obtained by surgery.

Results: Pathologic results were positive for peritoneal carcinomatosis in 26 patients and negative in 20 patients. PET/CT correctly detected 25 of 26 patients with peritoneal carcinomatosis and enhanced abdominal CT correctly detected 23 of 26 patients. Sensitivity and specificity for the diagnosis of peritoneal carcinomatosis were 96.2% and 90%, respectively, for PET/CT and 88.5% and 65%, respectively, for enhanced abdominal CT. The accuracy of PET/CT was statistically higher than that of enhanced abdominal CT (93.5% vs 78.3%, P = 0.039). Four distinctly abnormal PET/CT findings of single nodular, multiple nodular, diffuse, and mixed FDG uptakes were identified and corresponded to pathologic findings.

Conclusions: 18F-FDG PET/CT imaging is efficient in the diagnosis of peritoneal carcinomatosis and its performance is superior to that of enhanced abdominal CT.

© 2013 Lippincott Williams & Wilkins, Inc.

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