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Human Radiation Dose Estimation of 11C-CFT Using Whole-Body PET

Huang, Tingting MD; Wang, Hongliang PhD; Tang, Ganghua PhD; Liang, Xiang BM; Deng, Huaifu PhD; Yi, Chang MS; Zhang, Xiangsong PhD

Clinical Nuclear Medicine:
doi: 10.1097/RLU.0b013e318266cd1b
Original Articles
Abstract

Purpose: 11C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (11C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of 11C-CFT based on whole-body PET imaging in healthy subjects.

Methods: Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of 11C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method.

Results: The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E−03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine.

Conclusions: The potential radiation risks of 11C-CFT associated with in this study are well within accepted limits. 11C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year.

Author Information

From the Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.

Received for publication May 6, 2012; and revision accepted May 23, 2012.

Drs Huang and Wang contributed equally to this work.

Conflicts of interest and sources of funding: none declared.

Reprints: Ganghua Tang, PhD, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. E-mail: gtang0224@yahoo.com.cn.

© 2012 Lippincott Williams & Wilkins, Inc.