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Human Radiation Dose Estimation of 11C-CFT Using Whole-Body PET

Huang, Tingting MD; Wang, Hongliang PhD; Tang, Ganghua PhD; Liang, Xiang BM; Deng, Huaifu PhD; Yi, Chang MS; Zhang, Xiangsong PhD

doi: 10.1097/RLU.0b013e318266cd1b
Original Articles

Purpose 11C-Labeled 2-β-carbomethoxy-3-β-(4-fluorophenyl)tropane (11C-CFT) is a commonly used positron emission tomography (PET) tracer for dopamine transporters imaging. The present study estimated human radiation absorbed doses of 11C-CFT based on whole-body PET imaging in healthy subjects.

Methods Whole-body PET was performed on 6 subjects after injection of 472.06 ± 116.47 MBq of 11C-CFT. 7 Frames were acquired for about 70 min in 7 segments of the body. Regions of interest were drawn on PET images of source organs. Residence time was calculated as the area under the time-activity curve. Radiation dosimetry was calculated from organ residence time using the medical internal radiation dosimetry (MIDR) method.

Results The organs with the highest radiation-absorbed doses were the urinary bladder, followed the spleen, pancreas, kidneys, and stomach. The dose-limiting critical organ was the urinary bladder. The effective dose was 8.89E−03 mSv/MBq (22.9 mrem/mCi). Biexponential fitting of mean bladder activity demonstrated that 18% of activity was excreted via the urine.

Conclusions The potential radiation risks of 11C-CFT associated with in this study are well within accepted limits. 11C-CFT demonstrates a favorable radiation dose profile in humans and allows multiple PET examinations on the same subject per year.

From the Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China.

Received for publication May 6, 2012; and revision accepted May 23, 2012.

Drs Huang and Wang contributed equally to this work.

Conflicts of interest and sources of funding: none declared.

Reprints: Ganghua Tang, PhD, Department of Nuclear Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, China. E-mail: gtang0224@yahoo.com.cn.

Copyright © 2012 Wolters Kluwer Health, Inc. All rights reserved.