Abstract: A 35-year-old man presented with right lower extremity numbness and weakness. CT demonstrated an irregular left parietal hypoattenuation with a punctuate calcification. MRI revealed a T1 low signal and T2 high signal lesion with extensive surrounding edema. Gadolinium-enhanced MRI showed an irregular enhancing lesion. 18F-FDG and 11C-methionine PET both demonstrated high uptake in the left parietal lesion. Lesion SUV was 7.5 for 18F-FDG and 3.0 for 11C-methionine. Surgical pathology demonstrated cerebral sparganosis.