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SUV on Dual-Phase FDG PET/CT Correlates With the Ki-67 Proliferation Index in Patients With Newly Diagnosed Non-Hodgkin Lymphoma

Chang, Chin-Chuan MD*; Cho, Shih-Feng MD; Chen, Yu-Wen MD*‡; Tu, Hung-Pin PhD§; Lin, Chia-Yang MD*; Chang, Chao-Sung MD, PhD†∥

doi: 10.1097/RLU.0b013e318251e16e
Original Articles

Purpose: PET using 18F-FDG integrated with CT is beneficial for staging patients with non-Hodgkin lymphoma (NHL). The Ki-67 index is used to assess the proliferation potential of tumor cells. The aim of this study was to evaluate the correlation of the Ki-67 index in tissue samples with the SUV at different sites on dual-phase FDG PET/CT of patients with newly diagnosed NHL.

Materials and Methods: From September 2009 to March 2011, patients with newly diagnosed NHL who had received dual-phase FDG PET/CT for staging and biopsy samples that were evaluated for the Ki-67 expression were enrolled. The SUVmax of the biopsy site, the tumorous lesion sites, and 3 different bone marrow sites (right iliac crest, sternum, and L1) were measured. The SUVmean of the liver and spleen were also measured.

Results: There were a total of 27 patients in this study. Significant correlations were observed between the Ki-67 index and the SUVmax of the right iliac crest in patients with early-stage disease (stage I and II) patients, the SUVmax of the biopsy and whole-body lesion sites in patients with late-stage disease (stage III and IV), and the retention index of SUVmax of the right iliac crest in patients whose bone marrow were involved by lymphoma cells.

Conclusions: For patients with newly diagnosed NHL, the significant correlation between the Ki-67 index and the SUV in this study suggests that dual-phase FDG PET/CT may be used as a noninvasive measurement of tumor proliferation.

From the *Department of Nuclear Medicine, Kaohsiung Medical University Hospital, †Division of Hematology & Oncology, Department of Internal Medicine, ‡School of Medicine, and §Department of Public Health and Environmental Medicine, College of Medicine, and ||Graduate Institute of Healthcare Administration, Kaohsiung Medical University, Kaohsiung, Taiwan.

Received for publication June 21, 2011; revision accepted February 21, 2012.

Conflicts of interest and sources of funding: none declared.

Reprints: Chao-Sung Chang, MD, PhD, No. 100 Tzyou 1st Rd, Kaohsiung City, 80756, Taiwan. E-mail:

© 2012 Lippincott Williams & Wilkins, Inc.