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18F-FDG PET Detection of Unknown Primary Malignancy in Dermatomyositis

Mahmood, Syed MD*†; Rodríguez Martínez de Llano, Sofia MD, PhD

doi: 10.1097/RLU.0b013e318252d22a
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Abstract: Dermatomyositis is an inflammatory myopathy that has an association with malignancy in adults. We present a patient who initially presented with adenopathy and progressive muscular weakness and was diagnosed with dermatomyositis and lung carcinoma on further investigation. Whole-body PET/CT scan revealed diffuse proximal muscle hypermetabolism representing the inflammatory nature of dermatomyositis, and an intensely FDG-avid primary right lower lung small cell lung carcinoma and metastatic thoracic lymphadenopathy. PET/CT imaging may offer an “all-in-one” procedure as an alternative to other diagnostic procedures, reducing the number of unnecessary investigations in patients presenting with paraneoplastic syndromes searching for underlying malignancy.

From the *Department of Nuclear Medicine, Jacobi Medical Center and North Central Bronx Hospital, Bronx, NY; †GE Healthcare, Princeton, NJ; and ‡Nuclear Medicine, Centro Oncológico de Galicia, La Coruña, Galicia, Spain.

Received for publication July 19, 2011; revision accepted February 27, 2012.

There are no conflicts of interest associated with this publication. All institutional ethical standards have been adhered to in association with this publication.

Reprints: Syed Mahmood, MD, GE Healthcare, 101 Carnegie Center, Princeton, NJ 08540. E-mail: smahmood@yahoo.com.

© 2012 Lippincott Williams & Wilkins, Inc.