DETERMINATION OF THE POTENTIAL RISK FACTORS FOR ANTERIOR CRUCIATE LIGAMENT INJURY
Most anterior cruciate ligament (ACL) injuries in female sports occur during a noncontact episode, typically during deceleration, lateral pivoting, or landing tasks that are associated with high loads on the knee joint (Figure 1a) (7,58). Sports maneuvers may lead to high external knee loads in both sexes. Why these tasks result in greater incidence of ACL injury in women has, until recently, remained unclear. Three major etiological theories have been proposed to explain the sex disparity observed in ACL injury rates: anatomical, hormonal, and neuromuscular (18, 46). A number of studies of ACL injury risk factors have focused on anatomical or anthropometric measures, such as thigh length (5), joint laxity (55), and femoral notch width (65). However, static anatomical measures, such as Q-angle, often do not appear to correlate with the mechanics associated with the dynamic injury mechanism (47,50). Hormonal factors, particularly those associated with the follicular and ovulatory phases of the menstrual cycle, have also been linked to ACL injury risk (1,19,26,67,74,75,78). However, the precise means by which they may contribute to ACL injury risk and the extent to which these hormonal factors can be modified remains unclear (10).
DETERMINATION OF POTENTIAL MODIFIABLE RISK FACTORS FOR ANTERIOR CRUCIATE LIGAMENT INJURY IN WOMEN
The study of modifiable risk factors has focused on the working hypothesis that ACL injury risks are related to measurable deficits in neuromuscular control in female athletes (11,13,24). Neuromuscular control deficits are defined as muscle strength, power, or activation patterns that lead to increased knee joint and ACL loads (46). Female athletes demonstrate neuromuscular control deficits that increase lower extremity joint loads during sports activities (25).
One neuromuscular deficit, which is operationally termed “ligament dominance,” can be defined as an imbalance between the neuromuscular and ligamentous control of dynamic knee joint stability (46). This control imbalance is demonstrated by an inability to control lower extremity frontal plane motion during landing and cutting. A second modifiable neuromuscular control deficit often observed in female athletes, which is termed “quadriceps dominance,” can be defined as an imbalance between knee extensor and flexor strength, recruitment, and coordination (46). A third neuromuscular control deficit, often observed in female athletes, is “leg dominance,” which can be defined as an imbalance between the 2 lower extremities in strength, coordination, and control (46). The fourth and final neuromuscular control deficit, often observed in female athletes, is “trunk dominance 'core' dysfunction,” which can be defined as an imbalance between the inertial demands of the trunk and control and coordination to resist it.
During landing, pivoting, or deceleration, the motion of the female athlete's trunk is often excessive and directed, to a greater extent, by the body segment's inertia, than by the athlete's core muscle function. This decreased core control and ability to dissipate force result in excessive trunk motion, especially in the frontal plane, as well as high ground reaction forces and knee joint abduction torques (knee load) (22).
These 4 potential neuromuscular control deficits, operationally defined above, are postulated to be important contributors to knee and ACL injury incidence in female athletes (24,43,62,77). ACL injury likely occurs under conditions of high dynamic loading of the knee joint, when active muscular restraints do not compensate for and dampen joint loads adequately (Figure 1a) (6). Decreased neuromuscular control of the joint may place stress on the passive ligamentous structures that may exceed their strength limit and potentially lead to mechanical failure (34,39). External abduction moment (LOAD) is the laboratory-based kinetic measure that is predictive of future injury and likely contributes to the stress on an ACL during injury (Figure 1c and 1d) (24,64). The term “valgus” is used to describe the video-evidenced mechanism of injury (Figure 1a) and is visually associated with a knock-kneed position during dynamic tasks (Figure 1b).
Neuromuscular control of high-load movements is required to maintain dynamic knee stability during landing and pivoting (3,34). Deficits in the active neuromuscular control system likely affect dynamic knee stability and possibly increase the risk of an ACL injury. Methods to identify neuromuscular control deficits during tasks related to ACL injury mechanisms, such as landing, cutting, and decelerating, may offer the greatest potential for the development and application of neuromuscular screening interventions targeted to high-risk populations (7,58).
The authors currently use a 2-pronged approach to the prevention of ACL injuries in young female athletes. We incorporate both risk screening and dynamic neuromuscular training as dual interventions to prevent these devastating injuries. Myer et al. (45) demonstrated that those athletes who subject their knees to higher joint loads benefit to a greater extent from our dynamic neuromuscular training protocols than those who do not. Therefore, we first screen athletes for high-risk status and then intervene with neuromuscular training designed to ameliorate those specific neuromuscular imbalances that those specific athletes demonstrate. This dual approach likely results in greater efficacy of both avenues of intervention.
POTENTIAL MODIFIABLE RISK FACTORS ASSOCIATED WITH DYNAMIC MOVEMENTS
Hewett et al. (25) tested the hypothesis that insufficient neuromuscular control of lower limb biomechanics, particularly the knee joint, leads to high-risk patterns in female athletes during execution of common, albeit potentially hazardous, movements. The results of this study demonstrated that peak landing forces were significantly predicted by knee abduction torques (LOAD) at the knee in women, that women developed decreased relative knee flexor torque during landing compared with men, and that women had greater side-to-side differences in normalized hamstring peak torque compared with men.
Ford et al. (11) reported similar sex differences during the performance of a drop vertical jump (Figure 1b). This study determined that female athletes landed with a greater maximum valgus knee angle and greater total valgus knee motion than male athletes (Figure 1c). Female athletes also demonstrated significant differences between their dominant and nondominant side in maximum valgus knee angle. These differences in valgus measures (ligament dominance) and limb-to-limb asymmetries (leg dominance) reflect neuromuscular deficits that may be indicative of decreased dynamic knee joint control in female athletes (11).
Subsequent studies systematically evaluated neuromuscular control at the hip in female athletes (21,79). The evidence from multiple, potentially high-risk, movements indicated that variables at the hip contributed to dynamic valgus. In addition, electromyographic (EMG) data demonstrated women to men differences in firing patterns of the hip musculature (79). The purpose of these studies was to identify sex differences in hip motion, kinetics, and muscle firing patterns during single leg agility and landing maneuvers. It was hypothesized that female athletes would display increased hip adduction angles and external adduction moments during this multicomponent dynamic maneuver that may contribute to lower extremity valgus.
These results demonstrated that female athletes had greater hip adduction angles and torques than men during multidirectional single-leg landing. These differences were limited to the frontal plane and were not observed in the sagittal plane. EMG patterns showed increased quadriceps and decreased gluteal firing in women (79). Another study examined sex differences during single leg landings from either a medial or a lateral direction (14). In addition to greater knee abduction angles, female athletes also exhibited increased hip frontal plane excursion compared with male athletes during both types of landings (14). The increased hip adduction (hip varus) motion seen in the frontal plane during athletic activities likely contributes to the dynamic valgus knee position that may place the athlete at an increased risk of ACL injury (Figure 1d) (14,21).
PROLIFERATION OF ANTERIOR CRUCIATE LIGAMENT INJURY RISK FACTORS DURING ADOLESCENT GROWTH
Men demonstrate power, strength, and coordination increases with increasing chronological age that correlates to maturational stage, whereas women show significantly smaller changes throughout puberty (4,37). Correlations among height, weight, and neuromuscular performance observed in men are absent in pubescent girls. For example, vertical jump height (a measure of whole-body power) increases steadily in men during puberty but not in women (30,37,63). Musculoskeletal growth during puberty, in the absence of corresponding neuromuscular adaptation, may facilitate the development of certain intrinsic ACL injury risk factors (16,23). These intrinsic risk factors, if not addressed at the proper time, may continue through adolescence into maturity and predispose athletes to ACL injuries.
Neuromuscular training programs have been successful in reducing measures of knee abduction (25,45,53,54). A comprehensive review of ACL injury prevention programs indicates that neuromuscular training appears to decrease ACL injury rates in female athletes (20). These programs typically incorporate plyometric training and technique analysis. Ongoing studies show that knee abduction measures may be useful for the identification of those women who are at an increased risk of ACL injury (24). In a recent longitudinal study, Ford et al. (16) identified that during a landing task, pubertal girls have an increased change in knee abduction motion during a year of adolescent growth. In addition, important reported risk factors of knee abduction motion and torque were significantly greater across consecutive years in young postpubertal female athletes compared with men (16).
Figure 2a-c presents an example athlete whose combination of decreased tibia length and mass before her rapid growth spurt diminish risk to demonstrate high knee LOAD landing mechanics. Conversely, Figure 2d-f provides an example of an athlete whose combination of increased tibia length and mass associated with her rapid growth contribute to her increased risk to demonstrate high knee LOAD landing mechanics when using the clinic-based ACL injury risk prediction algorithm.
DETERMINING THE TIMING OF ATHLETE-SPECIFIC MATURATION
Somatic maturational assessments are traditionally the best way to identify rapid adolescent growth (37). The Khamis-Roche method of estimated adult stature was developed from the Fels Longitudinal Study that collected data on families residing in southwestern Ohio (31). The subject's stature, mass, midparental stature, and age were used to develop regression equations for boys and girls. This equation can be used to estimate the current percentage of height compared with their final estimated height.
Early puberty may be an appropriate time during maturation to institute intervention programs that aim to control knee abduction motion and torque as well as to induce a neuromuscular spurt through targeted neuromuscular training. The pubertal female group in our recent study was approximately 12 years old and estimated to be at 88% of adult stature (16). Therefore, training programs may be most beneficial before timing when girls are growing the fastest during adolescence (peak height velocity), which is near 92% of adult stature.
SCREENING FOR HIGH-RISK ATHLETES
Laboratory-based screening tools demonstrate that altered neuromuscular strategies or decreased neuromuscular control during the execution of sports movements, as evidenced by abnormal lower limb joint mechanics (motions and loads), may underlie the increased risk of ACL injury in female athletes (9,11,15,24,40,53). Prospective measures of external knee abduction moment during landing predict noncontact ACL injury risk in young female athletes (Figure 1a-d) (24).
Calculation of knee injury risk factors, such as knee abduction moment through inverse dynamics, requires complex laboratory-based 3-dimensional kinematic and kinetic measurement techniques. However, a recent report has isolated biomechanical measures that contribute to nearly 80% of the measured variance in knee abduction moment during landing (50). These biomechanical predictors of knee abduction moment, which include increased knee abduction angle, increased relative quadriceps recruitment, and decreased knee flexion range of motion, concomitant with the increased tibia length and mass normalized to body height that accompanies growth, are also measurements that have been related to the increased risk of ACL injury in previous prospective and retrospective epidemiological reports (7,24,59,69). Unfortunately, expensive biomechanical laboratories, with the costly and labor-intensive measurement tools to test individual athletes, are required for these measurements. This restricts the potential to perform athletes' risk assessments on a large scale, in particular limiting the potential to target high injury risk athletes with the appropriate intervention strategies.
To achieve the objective of reduction of noncontact ACL injury risk in female athletes, identification of those athletes who preferentially demonstrate high knee abduction moment landing mechanics appears salient. Therefore, a field-based assessment algorithm was systematically developed and validated that aimed to improve the potential to identify and target injury prevention training to female athletes with an increased knee abduction moment (49,51,52). The validated field-based assessment algorithm delineated 5 biomechanical factors that could be captured in clinic and field settings, which combined to identify high knee abduction moment during landing with high accuracy (49,51,52). This clinic-based assessment tool can be administered in a clinic or field setting, is validated by the highly accurate laboratory-based assessment, and can help to facilitate screening for ACL injury risk on a more widespread basis (Figure 2).
Although the clinic-based assessment tool is valuable to identify athletes who should be targeted with neuromuscular training, it was imperative to develop a “coach friendly” plyometric exercise landing assessment and technique training tool to target high-risk ACL injury mechanisms. For this reason, the tuck jump assessment tool was developed to aid coach's decision making during training sessions (Figure 3) (48).
REAL-TIME FIELD ASSESSMENT AND TRAINING TOOL
The tuck jump exercise may be useful to the strength coach for the identification of lower extremity technical flaws during a plyometric activity (Figure 4) (46). The tuck jump requires a high effort level from the athlete. Because of this, the strength coach may readily identify potential deficits (Figure 3), especially during the first few repetitions. In addition, the tuck jump exercise may be used to assess improvement in lower extremity biomechanics as the athlete progresses through their training (46,48).
Figure 3 provides the coach friendly landing technique assessment tool that strength coaches may use to monitor an athlete's performance of the tuck jump before, during, and after training. Specifically, the athlete performs repeated tuck jumps for 10 seconds, which allows the coach to visually grade the outlined criteria. To further improve accuracy of the assessment, a standard 2-dimensional camera in the frontal and sagittal planes may be used to assist the coach. The athlete's techniques (Figure 3) are subjectively rated as either having an apparent deficit (checked) or not. The deficits are then tallied for the final assessment score. Indicators of flawed techniques should be noted for each athlete and should be the focus of feedback during subsequent training sessions. The athlete's baseline performance can be compared with repeated assessments performed at the midpoint and conclusion of training protocols, to objectively track improvement with jumping and landing technique (Figure 3).
LIGAMENT DOMINANCE CRITERIA OF THE TUCK JUMP ASSESSMENT
For ease of presentation, criteria assessed using the tuck jump tool can be grouped into modifiable risk factor categories (Figure 5). As mentioned previously, ligament dominance is defined as an imbalance between the neuromuscular and ligamentous control of dynamic knee joint stability (46). This imbalance in control of dynamic knee joint stability is demonstrated by an inability to control lower extremity frontal plane motion during landing and cutting. External abduction moment (LOAD) is the laboratory-based kinetic measure that is predictive of future injury and likely contributes to the stress on an ACL during injury (Figure 1c and 1d) (24,64). The term “valgus” is used to describe the video-evidenced mechanism of injury (Figure 1a) and is visually associated with a knock-kneed position during dynamic tasks (Figure 1b). Figure 6 presents a “ligament dominant” athlete who lacks sufficient frontal plane control of her lower extremity during performance of the tuck jump. Figure 7 presents secondary assessment of ligament dominance with the criteria that assesses if foot placement is maintained shoulder width apart during landing. This athlete's reduced ligament dominant landing mechanics may be driven from the lack of frontal plane control at the hip, which may be improved with targeted training for the trunk and hip (41,42,46,54,61).
QUADRICEPS DOMINANCE CRITERIA OF THE TUCK JUMP ASSESSMENT
A second modifiable neuromuscular control deficit often observed in female athletes, which was termed “quadriceps dominance,” is defined as an imbalance between knee extensor and flexor strength, recruitment, and coordination (46). Landing with the knee at nearly full extension is a commonly associated mechanism of ACL injury (7). Decreased hamstrings strength relative to the quadriceps is implicated as a potential mechanism for increased lower extremity injuries (12,17,32,43,68) and potentially ACL injury risk in female athletes (46). Joint stability through co-contraction of hamstrings and quadriceps may be necessary when the joint experiences high quadriceps activation or when the passive structures are compromised (66,72). Withrow et al. (73) reported that increased hamstrings force during the flexion phase of simulated jump landings greatly decreased relative strain on the ACL.
Another proposed theory related to neuromuscular imbalances and increased ACL injury risk in women is the relatively low knee flexor-to-extensor recruitment that may be reflective of a closed-chain dynamic hamstrings/quadriceps peak torque output (25,38). For example, hamstrings activation can decrease the load on the passive restraints of the knee (36), increase the knee joint compression force, and stabilize the knee from external varus/valgus load (35). Hewett et al. reported that men demonstrated knee flexor moments (measured using inverse dynamics) that were 3-fold higher than those in women during deceleration from a landing (25). This group of women also demonstrated decreased isokinetic hamstrings to quadricep ratio and increased knee abduction (valgus) moments compared with male subjects. The increased knee valgus moment significantly correlated with the peak impact forces during the maneuver and is purported to increase ACL injury risk in female athletes (24,25). Ford et al. (12) reported that women showed an absence of matched increased hamstrings muscle activation relative to quadriceps and overall low amplitude during the landing phase of a jump.
This tendency of female athletes to preferentially activate the quadriceps relative to the hamstrings during high-demand activities may limit their abilities to maintain dynamic knee control during high-risk maneuvers. Athletes who demonstrate quadriceps dominance may increase their risk of ACL injury when they cut and land with low knee flexion angles. An athlete who lands with small knee flexion angles and flat foot position demonstrates characteristics of a quadriceps dominant athlete (Figure 8) and will likely demonstrate excessive landing contact noise. This criterion assessed using the tuck jump tool can be grouped into quadriceps dominance modifiable risk factor category (Figure 5) and if identified with the tuck jump assessment should be targeted with posterior chain and deep knee flexion exercises (43,44,46,53,54).
LEG DOMINANCE/RESIDUAL INJURY DEFICITS CRITERIA OF THE TUCK JUMP ASSESSMENT
A third neuromuscular control deficit, frequently observed in female athletes, is “leg dominance,” which is defined as an imbalance between the 2 lower extremities in strength, coordination, and control (46). Coaches should be cognizant during their risk assessment that side-to-side imbalances in neuromuscular strength, flexibility, and coordination can be important predictors of increased injury risk (2,24,32). Specific to ACL injury risk in female athletes, leg-to-leg differences in dynamic valgus measures were observed in injured but not in uninjured women. Importantly, side-to-side differences in knee LOAD were 6.4× greater in ACL-injured versus the uninjured women. Female athletes tend to demonstrate side-to-side differences in visually evident maximum knee valgus angle during a box drop vertical jump (11). In addition, female athletes often demonstrate leg-to-leg deficits following injury that increase their risk of subsequent injury (60,62). Leg dominance or residual injury deficits may be evident in the grouped tuck jump criteria including thighs not equal side to side during flight (Figure 9), foot placement not parallel (front-to-back) (Figure 10), and foot contact timing not equal (Figure 11). Athletes identified with leg-to-leg deficit should be targeted with integrated training that combines both plyometric and dynamic stabilization to improve leg-to-leg symmetry during dynamic tasks (44,53).
“CORE” DYSFUNCTION DOMINANCE CRITERIA OF THE TUCK JUMP ASSESSMENT
The fourth neuromuscular control deficit, often observed in female athletes, is “core” dysfunction dominance, which may be defined as an imbalance between the inertial demands of the trunk and core control and coordination to resist it. We have developed a concept of trunk and lower extremity function that identifies the body's core as a critical modulator of lower extremity alignments and loads during dynamic tasks (42). The trunk and hip stabilizers may preactivate to counterbalance trunk motion and regulate lower extremity postures (27,28,70). Reduced preactivation of the trunk and hip stabilizers may allow increased lateral trunk positions that can incite knee abduction loads (71).
Decreased “core stability” and muscular synergism of the trunk and hip stabilizers may affect performance in power activities and may increase the incidence of injury secondary to lack of control of the center of mass, especially in female athletes (29,60,62,76). Zazulak et al. reported that factors related to core stability predicted risk of knee injuries in female athletes but not in male athletes (77). Thus, the current evidence indicates that compromised function of the trunk and hip stabilizers, as they relate to core neuromuscular control, may underlie the mechanisms of increased ACL injury risk in female athletes (24,33,58,77).
Core dysfunction imbalance may be evident in the athlete's tuck jump criteria including thighs do not reach parallel (peak of jump) (Figure 12), pause between jumps, and the athlete does not land in the same footprint (Figure 13). Athletes identified with these deficits should be targeted with trunk and hip training to improve core control (41,42).
TECHNIQUE PERFECTION CRITERIA OF THE TUCK JUMP ASSESSMENT
The tuck jump assessment tool can be used to improve high-risk techniques during an exercise that requires a high effort level from the athlete. As suggested earlier, an athlete may place most of his or her cognitive efforts solely on the performance of this difficult jump and demonstrate many technical flaws that are indicative of increased risk for injury. However, if she can improve her neuromuscular control and biomechanics during this difficult jump and maintain control during the entire jump-landing sequence, she may gain dynamic neuromuscular control of the lower extremity and create a learned skill that can be transferred to competitive play (Figure 4). We recommend that athletes who do not improve their scores, or who demonstrate 6 or more flawed techniques, should be targeted for further technique training. These data indicate that the tuck jump assessment is best used for a single coach to reassess athletes to determine changes in technical performance of the tuck jump exercise (56,57).
EFFECT OF TRAINING ON TUCK JUMP ASSESSMENT CRITERIA
Cumulatively, research indicates that ACL intervention training can be used to reduce measured deficits during the tuck jump assessment and may help prevent risk of ACL injury. A pilot study was conducted to test the effects of pre-season and in-season neuromuscular training on the tuck jump assessment scores to determine if both training periods were vital to a training protocol (8). The data from this study indicates that pre-season neuromuscular training should be considered paramount within the yearly strength and conditioning program to help minimize the risk factors associated with ACL injury.
The tuck jump assessment allows a coach or clinician to evaluate an athlete's risk of injury and identify specific deficiencies. By using this test throughout the yearly training cycle, overall progress can be monitored and training can be more thoroughly directed. The results also indicate a potential dose-response to the neuromuscular training targeted to prevent ACL injury training. Preliminary results indicate that additional training throughout the competitive season has added benefits in terms of reducing risk of ACL injury based on improvements to the athlete's tuck jump assessment score. Future research is warranted to determine the relationship of reduced deficits gained from the utilization of the presented techniques with actual reduction of injury in athletes treated with targeted training.
To achieve the objective of reduction of noncontact ACL injury risk in female athletes, identification and treatment of those who preferentially demonstrate “high-risk” landing mechanics appears salient. The provided tuck jump assessment tool provides an integrated approach to guide targeted dynamic neuromuscular analysis training to specifically address and correct neuromuscular deficits that increase high LOAD risk within the algorithm. Theoretically, through identification of female athletes at greater risk for ACL injury, prevention strategies to reduce an ACL injury could be substantially improved. Current nontargeted neuromuscular training programs require application to 89 female athletes to prevent one ACL injury (18).
Female athletes, who demonstrate “high-risk” landing mechanics, are at an increased risk for ACL injury and are more likely to benefit from neuromuscular training targeted to these risk factors (45). Utilization of the developed field-based assessment and training tool may guide the application of appropriate interventions that will have greater potential to reduce their injury risk. Targeted correction of high-risk factors for injury is important for both optimal biomechanics of athletic movements that maximize sport performance and ultimately the reduction of knee ligament injury incidence in female athletes.
The authors thank Boone County Kentucky, School District, especially School Superintendent Randy Poe, for participation in this project. They also thank Mike Blevins, Ed Massey, Dr Brian Blavatt, and the athletes of Boone County public school district for their participation. They also acknowledge the Cincinnati Children's Sports Medicine Biodynamics Center Team who contributed both physically and intellectually to the presented research outcomes.
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