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Muscle Mass Gain After Resistance Training Is Inversely Correlated With Trunk Adiposity Gain in Postmenopausal Women

Orsatti, Fábio L.1; Nahas, Eliana A.P.2; Orsatti, Cláudio L.2; de Oliveira, Erick P.3,4; Nahas-Neto, Jorge2; da Mota, Gustavo R.1; Burini, Roberto C.3,4

Journal of Strength & Conditioning Research: August 2012 - Volume 26 - Issue 8 - p 2130–2139
doi: 10.1519/JSC.0b013e318239f837
Original Research

Abstract: Orsatti, FL, Nahas, EAP, Orsatti, CL, de Oliveira, EP, Nahas-Neto, J, da Mota, GR, and Burini, RC. Muscle mass gain after resistance training is inversely correlated with trunk adiposity gain in postmenopausal women. J Strength Cond Res 26(8): 2130–2139, 2012—The aim of this study was to evaluate alterations in trunk adiposity (TA) over 9 months of resistance training (RT) and associate these changes with the hypertrophy of muscle mass (MM) in postmenopausal women (PW). The investigation used a sample that consisted of 22 PW (44–69 years old). The group was subjected to RT (60–80% of 1 repetition maximum) for the total body 3 d·wk−1. Body composition (dual-energy x-ray absorptiometry) and plasma levels of insulin-like growth factor-1 (IGF-1), follicle-stimulating hormone, E2 (Immulite system), and interleukin-6 (IL-6; enzyme-linked immunosorbent assay) were assessed at the beginning and end of the experiment. After RT, only women who acquired up to 5% TA gained MM, whereas women who acquired >5% TA exhibited increased IL-6 and no MM gain (p < 0.05). The ΔMM was negatively associated with time of menopause (r = −0.45, p < 0.05) and positively associated with baseline IGF-1 (r = 0.47, p < 0.05). Only ΔLE (leg extension) was negatively associated with baseline IL-6 (p < 0.05). Trunk adiposity growth (ΔTF, kilograms) was positively correlated with changes in IL-6 (r = 0.68, p < 0.05). The MM gain was negatively correlated with ΔTF (r = −0.63, p < 0.05) and changes in IL-6 (r = −0.73, p < 0.05). After adjusting all of the confounding variables, only baseline IGF-1 (positively) and changes in IL-6 (negatively) influenced MM, and only the increase in TA influenced IL-6. Our study suggests that increased levels of TA during RT increase IL-6 concentrations, which is a significant negative predictor of MM gain in PW.

1Exercise Biology Laboratory (BioEx), Health Science Institute, Triângulo Mineiro Federal University (UFTM), Uberaba, Minas Gerais, Brazil

2Climacterium and Menopause Sector from the Department of Gynecology and Obstetrics, Botucatu School of Medicine, UNESP, Botucatu, São Paulo, Brazil

3Department of Pathology, Botucatu School of Medicine, UNESP, Botucatu, São Paulo, Brazil

4Exercise and Nutrition Metabolism Center from the Department of Public Health, Botucatu School of Medicine, UNESP, Botucatu, São Paulo, Brazil

Address correspondence to Fábio Lera Orsatti, fabiorsatti@gmail.com.

© 2012 National Strength and Conditioning Association