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Journal of Strength & Conditioning Research:
doi: 10.1519/JSC.0b013e31822a5cfe

Metabolic and Cardiac Autonomic Effects of High-Intensity Resistance Training Protocol in Wistar Rats

de Deus, Ana Paula1; de Oliveira, Claudio Ricardo2; Simões, Rodrigo Polaquini1; Baldissera, Vilmar3; da Silva, Carlos Alberto4; Rossi, Bruno Rafael Orsini5; de Sousa, Hugo Celso Dutra5; Parizotto, Nivaldo Antonio1; Arena, Ross6,7; Borghi-Silva, Audrey1

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Deus, AP, Oliveira, CR, Simões, RP, Baldissera, V, Silva, CA, Rossi, BRO, Sousa, HCD, Parizotto, NA, Arena, R, and Borghi-Silva, A. Metabolic and cardiac autonomic effects of high-intensity resistance training protocol in Wistar rats. J Strength Cond Res 26(3): 618–624, 2012—The aim of this study was to assess the effects of metabolic and autonomic nervous control on high-intensity resistance training (HRT) as determined by pancreatic glucose sensitivity (GS), insulin sensitivity (IS), blood lactate ([La]), and heart rate variability (HRV) in rats. Thirty male, albino Wistar rats (292 ± 20 g) were divided into 3 groups: sedentary control (SC), low-resistance training (LRT), and HRT. The animals in the HRT group were submitted to a high-resistance protocol with a progressively increasing load relative to body weight until exhaustion, whereas the LRT group performed the same exercise regimen with no load progression. The program was conducted 3 times per week for 8 weeks. The [La], parameters related to the functionality of pancreatic tissue, and HRV were measured. There was a significant increase in peak [La] only in the HRT group, but there was a reduction in [La] when corrected to the maximal load in both trained groups (LRT and HRT, p < 0.05). Both trained groups exhibited an increase in IS; however, compared with SC and LRT, HRT demonstrated a significantly higher GS posttraining (p < 0.05). With respect to HRV, the low-frequency (LF) band, in milliseconds squared, reduced in both trained groups, but the high-frequency band, in milliseconds squared and nu, increased, and the LF in nu, decreased only in the HRT group (p < 0.05). The HRT protocol produced significant and beneficial metabolic and cardiac autonomic adaptations. These results provide evidence for the positive benefits of HRT in counteracting metabolic and cardiovascular dysfunction.

© 2012 National Strength and Conditioning Association



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