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Metabolic and Cardiac Autonomic Effects of High-Intensity Resistance Training Protocol in Wistar Rats

de Deus, Ana Paula1; de Oliveira, Claudio Ricardo2; Simões, Rodrigo Polaquini1; Baldissera, Vilmar3; da Silva, Carlos Alberto4; Rossi, Bruno Rafael Orsini5; de Sousa, Hugo Celso Dutra5; Parizotto, Nivaldo Antonio1; Arena, Ross6,7; Borghi-Silva, Audrey1

Journal of Strength & Conditioning Research: March 2012 - Volume 26 - Issue 3 - pp 618-624
doi: 10.1519/JSC.0b013e31822a5cfe
Original

Deus, AP, Oliveira, CR, Simões, RP, Baldissera, V, Silva, CA, Rossi, BRO, Sousa, HCD, Parizotto, NA, Arena, R, and Borghi-Silva, A. Metabolic and cardiac autonomic effects of high-intensity resistance training protocol in Wistar rats. J Strength Cond Res 26(3): 618–624, 2012—The aim of this study was to assess the effects of metabolic and autonomic nervous control on high-intensity resistance training (HRT) as determined by pancreatic glucose sensitivity (GS), insulin sensitivity (IS), blood lactate ([La]), and heart rate variability (HRV) in rats. Thirty male, albino Wistar rats (292 ± 20 g) were divided into 3 groups: sedentary control (SC), low-resistance training (LRT), and HRT. The animals in the HRT group were submitted to a high-resistance protocol with a progressively increasing load relative to body weight until exhaustion, whereas the LRT group performed the same exercise regimen with no load progression. The program was conducted 3 times per week for 8 weeks. The [La], parameters related to the functionality of pancreatic tissue, and HRV were measured. There was a significant increase in peak [La] only in the HRT group, but there was a reduction in [La] when corrected to the maximal load in both trained groups (LRT and HRT, p < 0.05). Both trained groups exhibited an increase in IS; however, compared with SC and LRT, HRT demonstrated a significantly higher GS posttraining (p < 0.05). With respect to HRV, the low-frequency (LF) band, in milliseconds squared, reduced in both trained groups, but the high-frequency band, in milliseconds squared and nu, increased, and the LF in nu, decreased only in the HRT group (p < 0.05). The HRT protocol produced significant and beneficial metabolic and cardiac autonomic adaptations. These results provide evidence for the positive benefits of HRT in counteracting metabolic and cardiovascular dysfunction.

1Cardiopulmonary Physiotherapy Laboratory, Physiotherapy Department, Federal University of Sao Carlos, São Carlos, Brazil; 2Medicine Department, Federal University of Sao Carlos, São Carlos, Brazil; 3Physiological Sciences Department, Federal University of Sao Carlos, São Carlos, Brazil; 4Healthy Sciences Department, Methodist University of Piracicaba, Piracicaba, Brazil; 5Physiotherapy Department, Medicine Faculty of Ribeirão Preto, Estadual University of São Paulo, Ribeirão Preto, Brazil; 6Department of Physical Therapy, Virginia Commonwealth University, Richmond, Virginia; and 7Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia

Address correspondence to Audrey Borghi-Silva, audrey@ufscar.br.

© 2012 National Strength and Conditioning Association