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Recovery after Heavy Resistance Exercise and Skeletal Muscle Androgen Receptor and Insulin-Like Growth Factor-I Isoform Expression in Strength Trained Men

Ahtiainen, Juha P1; Lehti, Maarit2; Hulmi, Juha J1; Kraemer, William J3; Alen, Markku4; Nyman, Kai5; Selänne, Harri2; Pakarinen, Arto6; Komulainen, Jyrki2; Kovanen, Vuokko7; Mero, Antti A1; Häkkinen, Keijo1

The Journal of Strength & Conditioning Research: March 2011 - Volume 25 - Issue 3 - p 767-777
doi: 10.1519/JSC.0b013e318202e449
Original Research

Ahtiainen, JP, Lehti, M, Hulmi, JJ, Kraemer, WJ, Alen, M, Nyman, K, Selänne, H, Pakarinen, A, Komulainen, A, Kovanen, V, Mero, AA, and Häkkinen, K. Recovery after heavy resistance exercise and skeletal muscle androgen receptor and insulin-like growth factor-I isoform expression in strength trained men. J Strength Cond Res 25(3): 767-777, 2011-The effects of heavy resistance exercise on skeletal muscle androgen receptor (AR) protein concentration and mRNAs of AR, insulin-like growth factor-I (IGF)-IEa, and mechano growth factor (MGF) expression were examined from biopsies of vastus lateralis (VL) muscle before and 48 hours after heavy resistance exercise (5 × 10 repetition maximum [RM] leg press and 4 × 10RM squats) in 8 adult strength trained men. The present exercise induced an acute decrease in maximal isometric force and increased serum total testosterone (T) and free testosterone (FT) concentrations. During 2 recovery days, maximal isometric force and subjective perception of physical fitness remained significantly lowered, whereas serum creatine kinase activity, subjective muscle soreness, and muscle swelling (i.e., thickness of VL by ultrasound) were significantly increased compared to pre-exercise values. Subjective perception of physical fitness was followed up to 7 days, and by 6 days postexercise, it was elevated above the pre-exercise level. Basal T and FT concentrations remained unaltered after the exercise. No statistically significant changes were observed in AR protein or mRNA expression, but IGF-IEa (p < 0.05) and MGF (p < 0.05) mRNA expression were increased compared to pre-exercise levels. These findings indicate that IGF-IEa and MGF responses may be related to acute regenerative processes in muscle because of exercise and may contribute to muscular adaptation to resistance exercise. Subjective perception of physical fitness suggests that recovery over a pre-exercise level of the present type of heavy resistance exercise can take approximately 6 days.

1Department of Biology of Physical Activity and Neuromuscular Research Center, University of Jyväskylä, Jyväskylä, Finland; 2LIKES Research Center for Sport and Health Sciences, Jyväskylä, Finland; 3Human Performance Laboratory, Department of Kinesiology and Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut; 4Department of Medical Rehabilitation, Oulu University Hospital, Oulu and Institute of Health Sciences, University of Oulu, Oulu, Finland; 5Jyväskylä Central Hospital, Jyväskylä, Finland; 6Department of Clinical Chemistry, University of Oulu, Oulu, Finland; and 7Department of Health Sciences and Finnish Centre for Interdisciplinary Gerontology, University of Jyväskylä, Jyväskylä, Finland

Address correspondence to juha.ahtiainen@jyu.fi.

© 2011 National Strength and Conditioning Association