Thornton, MK, Rossi, SJ, and McMillan, JL. Comparison of two different resistance training intensities on excess post-exercise oxygen consumption in African American women who are overweight. J Strength Cond Res 25(2): 489-496, 2011-The purpose of this study was to compare a low- and high-intensity resistance exercise session of equal work on excess post-exercise oxygen consumption (EPOC). Ten African American (AA) overweight women performed a no-exercise control (CN) session, 3 sets of 9 resistance training exercises, for 15 repetitions (reps) at 45% of their 8-repetition maximum (RM) during 1 session (LO) and for 8 reps at 85% of their 8-RM during another session (HI). For each session heart rate (HR), ventilation volume (VE), oxygen consumption (V̇o2), and respiratory exchange ratio, were collected continuously from 15 minutes pre exercise until 30 minutes post exercise. Blood lactate ([Lac]b) was collected pre, immediately post, 15 and 30 minutes post exercise. No significant differences were found between sessions for any pre-exercise measurements (p > 0.05). During exercise, there was no significant difference between the HI and LO sessions, as expected. The [Lac]b immediately post and 15-minute post were significantly higher in both HI and LO sessions compared with the CN session, however; no significant differences were found between the HI and LO sessions. Post-exercise HR for the HI session was significantly greater than the CN session (p = 0.006) but not different from the LO session. There were no significant differences in post-exercise V̇o2 between the HI and LO sessions. A trend was observed between exercise sessions with EPOC for HI (1.26 ± 0.567 L·O2) vs. LO (0.870 ± 0.394 L·O2) sessions. These data suggest that resistance training at either a low or high intensity with an equated work volume will produce similar exercise and post-exercise oxygen consumption for AA overweight women. Both of these resistance training programs were well tolerated and could be used for sedentary populations without a preconditioning program.