The Mechanisms of Muscle Hypertrophy and Their Application to Resistance TrainingSchoenfeld, Brad JJournal of Strength & Conditioning Research: October 2010 - Volume 24 - Issue 10 - pp 2857-2872 doi: 10.1519/JSC.0b013e3181e840f3 Brief Review Abstract Author Information Schoenfeld, BJ. The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res 24(10): 2857-2875, 2010-The quest to increase lean body mass is widely pursued by those who lift weights. Research is lacking, however, as to the best approach for maximizing exercise-induced muscle growth. Bodybuilders generally train with moderate loads and fairly short rest intervals that induce high amounts of metabolic stress. Powerlifters, on the other hand, routinely train with high-intensity loads and lengthy rest periods between sets. Although both groups are known to display impressive muscularity, it is not clear which method is superior for hypertrophic gains. It has been shown that many factors mediate the hypertrophic process and that mechanical tension, muscle damage, and metabolic stress all can play a role in exercise-induced muscle growth. Therefore, the purpose of this paper is twofold: (a) to extensively review the literature as to the mechanisms of muscle hypertrophy and their application to exercise training and (b) to draw conclusions from the research as to the optimal protocol for maximizing muscle growth. Global Fitness Services, Scarsdale, New York Address correspondence to Brad Schoenfeld, email@example.com. Copyright © 2010 by the National Strength & Conditioning Association.