Lagally, KM, Cordero, J, Good, J, Brown, DD, and McCaw, ST. Physiologic and metabolic responses to a continuous functional resistance exercise workout. J Strength Cond Res 23(2): 373-379, 2009-The purpose of this study was to evaluate the physiologic and perceptual responses to a continuous functional exercise workout. Ten men and 10 women (21.2 ± 2.4 and 21.0 ± 1.5 years) completed a maximal oxygen uptake test, strength test, and body composition analysis. Subjects then participated in 3 familiarization sessions, during which they followed a videotaped routine that consisted of a series of functional resistance exercises performed in a continuous manner. Subjects performed the same routine in a final session, during which V̇O2, V̇co2, respiratory exchange ratio (RER), RPE, and heart rate were measured and blood samples were taken and analyzed for blood lactic acid concentration. Descriptive statistics were calculated for RPE, RER, blood lactic acid concentration, energy expenditure, and absolute and relative oxygen uptake and heart rate. Energy expenditure was calculated using V̇O2 and RER. Independent t-tests were used to examine differences between men and women for oxygen consumption, weight lifted, and energy expenditure during the workout. Subjects had a mean V̇o2 of 27.8 ml·kg−1·min−1 (51% of V̇o2 peak and 47.8% of V̇o2 reserve), a mean heart rate of 156 bpm (83% of maximum heart rate), and a mean RER of 0.91. The mean RPE was 5.9, and the mean difference between pre and post lactic acid concentration was 2.5 mmol·L−1. The mean total caloric expenditure was 289 kcal. Men lifted significantly heavier weights and expended more total calories than women. Caloric expenditure (kcal·kg−1·min−1), V̇o2, and weight lifted were similar between men and women when expressed relatively. Performing dynamic functional exercises in a continuous manner resulted in energy expenditure values, but not relative V̇o2 values, that meet the American College of Sports Medicine recommendations.