How do metabolic syndrome and time spent in the ICU contribute to cognitive decline?
Two separate studies have identified metabolic syndrome and time spent in the intensive care unit (ICU) as independent risk factors for cognitive decline. The first analysis, which used data on 2,975 people, ages 60 and older, from the Centers for Disease Control and Prevention’s National Health and Nutrition Examination Survey, found that those respondents with metabolic syndrome had an odds ratio of 1.40 for cognitive decline, compared to those without metabolic syndrome (p=.034). These data were presented at the American Neurological Association’s annual meeting last October; the full discussion and findings are available here: http://bit.ly/IFc3y9.
The second report, from the Bringing to Light the Risk Factors and Incidence of Neuropsychological Dysfunction in ICU Survivors (BRAIN-ICU) study, found that among 821 adult patients who had experienced episodes of delirium while in the ICU for respiratory failure, cardiogenic or septic shock, although only 6 percent had cognitive deficits at baseline, more than 50 percent developed measurable symptoms of cognitive impairment three and 12 months after discharge. The findings were reported in the Oct. 3 issue of the New England Journal of Medicine, and in a Nov. 7 article in Neurology Today: http://bit.ly/IKCJ10.
Here, in a video interview, Neurology Today Editor-in-chief Steven P. Ringel, MD, and Associate Editor Robert G. Holloway Jr., MD, MPH, provide insights into these two analyses, and discuss their potential clinical implications for treating patients in the ICU setting and after discharge.
November 7, 2013, Volume 13, Issue 21;